胸腹腔灌注化疗序贯高频热疗在老年恶性胸腹腔积液患者中的应用效果  

Effect of intrathoracic-intraperitoneal perfusion chemotherapy followed by high-frequency hyperthermia therapy in elderly patients with malignant pleural and peritoneal effusions

作　　者：王平[1] 王艳秋 乔辉 高姣 张凯利 赵美淑 Wang Ping;Wang Yanqiu;Qiao Hui;Gao Jiao;Zhang Kaili;Zhao Meishu(Department of Hematology,Tai'an City Central Hospital,Tai'an 271000,China)

机构地区：[1]山东省泰安市中心医院肿瘤血液科,271000

出　　处：《中华老年病研究电子杂志》2024年第2期15-19,共5页Chinese Journal of Geriatrics Research(Electronic Edition)

摘　　要：目的探讨胸腹腔灌注化疗序贯高频热疗在老年恶性胸腹腔积液患者中的应用效果。方法选取2022年1月至2023年1月泰安市中心医院收治的老年恶性胸腹腔积液患者200例,其中单独接受胸腹腔灌注化疗患者100例(对照组),接受胸腹腔灌注化疗序贯高频热疗100例(观察组)。治疗后,超声测定胸腹腔积液含量以评价近期疗效,同时观察两组患者肿瘤标志物水平、生活质量水平及不良反应发生情况。计量资料的比较采用t检验,计数资料的比较采用χ^(2)检验结果观察组总有效率较对照组显著提升(81.00%、68.00%,χ^(2)=4.448,P<0.05),癌胚抗原、糖类抗原125和糖类抗原199等肿瘤标志物水平较对照组下降更为显著(t=4.574、7.125、14.153,P<0.01),且卡氏评分提高率显著高于对照组(82.00%、69.00%,χ^(2)=4.568,P<0.05),但两组患者消化道症状、中性粒细胞减少、血小板减少、肝功能不全、肾功能不全等不良反应发生率的差异无统计学意义(χ^(2)=0.130、0.177、0.411、0.072、0.096,P>0.05)。结论胸腹腔灌注化疗序贯高频热疗应用于老年恶性胸腹腔积液患者,可有效改善近期疗效,降低肿瘤标志物水平,提高生活质量。Objective To investigate the effect of intrathoracic-intraperitoneal perfusion chemotherapy followed by high-frequency hyperthermia therapy in elderly patients with malignant pleural and peritoneal effusions.Methods A total of 200 elderly patients with malignant pleural and peritoneal effusions who were admitted to Tai'an City Central Hospital from January 2022 to January 2023 were selected.One hundred patients who received intrathoracic-intraperitoneal perfusion chemotherapy alone were assigned to the control group,and the other 100 patients who received intrathoracic-intraperitoneal perfusion chemotherapy followed by high-frequency hyperthermia were assigned to the observation group.After treatment,the amount of pleural and peritoneal effusion was measured under B-mode ultrasound to compare the short-term effects between the two groups.Additionally,the levels of tumor markers,quality of life,and adverse reactions were observed in both groups.T test was used to compare the measurement data,and Chi-square test was used to compare the counting data.Results The total effective rate in the observation group was significantly higher than that in the control group(81.00%vs.68.00%;χ^(2)=4.448,P<0.05).The levels of tumor markers such as carcinoembryonic antigen,carbohydrate antigen 125,and carbohydrate antigen 199 decreased more significantly in the observation group compared with those in the control group(t=4.574,7.125,14.153;P<0.01).The improvement rate of Karnofsky score was significantly higher in the observation group than that in the control group(82.00%vs.69.00%;χ^(2)=4.568,P<0.05).However,there was no statistically significant difference in the incidence of adverse reactions(including gastrointestinal symptoms,neutropenia,thrombocytopenia,liver insufficiency,and renal insufficiency)between the two groups(χ^(2)=0.130,0.177,0.411,0.072,0.096;P>0.05).Conclusion Intrathoracic-intraperitoneal perfusion chemotherapy followed by high-frequency hyperthermia therapy is safe and reliable in elderly patients with malig

关 键 词：恶性胸腹腔积液 老年 胸腹腔灌注化疗 高频热疗 疗效 安全性 

分 类 号：R730.5[医药卫生—肿瘤]