Intraoperative targeted blood pressure management and dexmedetomidine on composite complications in moderate-to-high risk patients after major abdominal surgery  

作　　者：Qiongfang Wu Haifeng Wang Meilin Li Wenjun Hu Shuting He Yanling Sun Dongliang Mu Daniel ISessler Dongxin Wang 

机构地区：[1]Department of Anesthesiology,Peking University First Hospital,Beijing 100034,China [2]Department of Anesthesiology,the 305th Hospital of the Chinese People’s Liberation Army,Beijing 100017,China [3]Outcomes Research Consortium,Huston,Texas 44195,USA [4]Department of Anesthesiology and Center for Outcomes Research,University of Texas Health Science Center,Houston,Texas 44195,USA

出　　处：《Chinese Medical Journal》2025年第2期240-242,共3页中华医学杂志(英文版)

基　　金：supported by grants from the National Key Research&Development Program of China(Nos.2023YFC2506900 and 2018YFC2001800);the National High Level Hospital Clinical Research Funding(Nos.2022CR74 and 2022CR78 of Peking University First Hos pital);Braun Anesthesia Scientific Research Fund(No.BBDF-2019-004).

摘　　要：To the Editor:Postoperative organ injuries and complications are the leading causes of perioperative morbidity and mortality.Although many retrospective studies have revealed the association between intraoperative hypotension and perioperative organ injury,[1]the results of prospective randomized trials with regard to tight blood pressure management and clinical outcomes were inconsistent.[2–4]Organ injury could be also provoked by surgery-induced stress.Dexmedetomidine has been validated to attenuate the over-expression of stress mediators;however,whether perioperative dexmedetomidine can improve clinical outcomes remains uncertain.[5,6]Therefore,this 2×2 factorial randomized trial was designed to investigate whether targeted blood pressure management with/without dexmedetomidine administration could minimize the occurrence of a composite of major organ injuries and complications within 30 days in moderateto-high risk patients after major non-cardiac surgery.

关 键 词：major abdominal surgery composite complications tight blood pressure management DEXMEDETOMIDINE prospective randomized trials intraoperative blood pressure management moderate high risk patients retrospective studies 

分 类 号：R614[医药卫生—麻醉学]