ITGA7在胶质母细胞瘤中的研究进展  

Advances in ITGA7 in glioblastomas

作　　者：韩鸿禧 苏元萍 王波 李金文 袁国强[2,4] HAN Hongxi;SU Yuanping;WANG Bo;LI Jinwen;YUAN Guoqiang(Department of Neurosurgery,The Second Hospital of Lanzhou University,Lanzhou 730000,Gansu Province,China;Laboratory of Neurosurgery,The Second Hospital of Lanzhou University,Lanzhou 730000,Gansu Province,China;Department of General Surgery,Affiliated Hospital of Gansu University of Traditional Chinese Medicine,Lanzhou 730000,Gansu Province,China;Academician Workstation,The Second Hospital of Lanzhou University,Lanzhou 730000,Gansu Province,China)

机构地区：[1]兰州大学第二医院神经外科,甘肃兰州730000 [2]兰州大学第二医院神经外科实验室,甘肃兰州730000 [3]甘肃中医药大学附属医院普外科,甘肃兰州730000 [4]兰州大学第二医院院士专家工作站,甘肃兰州730000

出　　处：《肿瘤》2024年第4期422-431,共10页Tumor

基　　金：甘肃省自然科学基金(22JR5R959)

摘　　要：胶质母细胞瘤(glioblastoma,GBM)是一种广泛发生且具有高度侵袭性的中枢神经系统肿瘤,其发生和发展与多种分子作用机制密切相关,治疗和预后仍然具有一定的挑战性。整合素α7(integrinα7,ITGA7)是一种潜在的神经胶质瘤干细胞标志物,其高表达与多种肿瘤的不良预后有关。近年来,有关ITGA7在GBM发病机制中的研究逐渐增多。因此,本文将就ITGA7在促进GBM进展方面的相关研究,包括GBM细胞的生物学行为、血管生成、信号通路以及肿瘤微环境等进行综述,以期为进一步揭示GBM发生和发展的机制和治疗靶点的发掘提供参考依据。Glioblastoma(GBM)is a widely occurring and highly invasive central nervous system tumor.Its occurrence and development are closely related to multiple molecular mechanisms,making treatment and prognosis challenging.Integrinα7(ITGA7)is a potential marker for glioblastoma stem cells,and its high expression is associated with poor prognosis in various solid tumor patients.In recent years,research on the pathogenesis of GBM involving ITGA7 has increased.This review summarizes recent studies on the role of ITGA7 in promoting GBM progression,including GBM cell biology,angiogenesis,signaling pathways,and the tumor microenvironment,with the aim of providing references for further understanding the mechanisms of GBM occurrence and development and the exploration of therapeutic targets.

关 键 词：胶质母细胞瘤 整合素α7 细胞增殖 细胞侵袭 信号通路 

分 类 号：R739.41[医药卫生—肿瘤]