Adaptor Proteins in Neuronal Development and Neurological Disorders:A Comprehensive Review of Their Roles and Importance  

作　　者：Junjie Zhang Ye Cheng Qinghe Xing 

机构地区：[1]Children’s Hospital of Fudan University and Institutes of Biomedical Sciences of Fudan University,Wanyuan Road 399,Shanghai,201102,China [2]Shanghai Center for Women and Children’s Health,Shanghai,200062,China

出　　处：《Journal of Bio-X Research》2024年第2期45-55,共11页生物组学研究杂志(英文)

基　　金：supported by the Shanghai Municipal Commission of Science and Technology Research Project(19JC1411001);the National Key Research and Development Program from the Ministry of Science and Technology of the People’s Republic of China(2021YFC2700800);the National Natural Science Foundation of China(31972880,32170615,31371274,and U21A20347);the National Key Research and Development Plan for Stem Cell and Transformation Research(2017YFA0104202);the Collaborative Innovation Center Project Construction for Shanghai Women and Children’s Health.

摘　　要：Neurons are polarized cells with a complex and unique morphology.Each specific type of neuron has distinct functional organelles and protein compositions.This compartmental complexity relies on adaptor protein(AP)complexes transporting intracellular components to target locations.Malfunctions in the AP complexes can result in a range of abnormalities in neurons that affect neuronal migration,axogenesis,dendritogenesis,neuronal protection,and neural differentiation.These abnormalities also have crucial consequences for the proper functioning of the nervous system.In this article,we review the neuronal functions of AP complexes and provide a comprehensive overview of their links to neurological diseases.

关 键 词：ap complexes neuronal development neuronal migration functional organelles adaptor proteins axogenesis neurological disorders polarized cells 

分 类 号：R741[医药卫生—神经病学与精神病学]