钙卫蛋白S100A8/S100A9在阿尔茨海默病中的研究进展  

Research progress of calprotectin S100A8/S100A9 in Alzheimer’s disease

作　　者：吴金丽 杨晓娟[2] WU Jinli;YANG Xiaojuan(The First Clinical Medical College,Shanxi Medical University,Taiyuan 030000,China;Department of Geriatrics,the First Hospital of Shanxi Medical University,Taiyuan 030000,China)

机构地区：[1]山西医科大学第一临床医学院,山西省太原市030000 [2]山西医科大学第一医院老年病科,山西省太原市030000

出　　处：《实用老年医学》2025年第2期197-201,共5页Practical Geriatrics

基　　金：山西省留学人员科技择优自主项目(20200008);山西省基础研究计划(202103021224398)。

摘　　要：AD是一种以进行性记忆丧失为特征的疾病。基于微生物-肠-脑轴这一新兴学说,我们认为肠道菌群变化可以激活肠道炎症反应。钙卫蛋白作为肠道炎症标志物,是AD脑肠轴学说中的关键物质,其亚基S100A8、S100A9也分别与AD中的β-淀粉样蛋白(Aβ)学说、神经炎症学说密切相关。本文归纳了S100A8/S100A9蛋白的主要功能及其在AD发病中的相关机制、危险因素、预防和治疗方面的新进展,以期为AD的治疗提供新的研究方向。Alzheimer’s disease(AD)is characterized by progressive memory loss.Based on the emerging theory of microbe-gut-brain axis,the changes in intestinal flora might activate the intestinal inflammation.Calprotectin,as a marker of intestinal inflammation,is a key substance in the brain-gut axis of AD.Its subunits S100A8 and S100A9 are also closely related to the Aβtheory and neuroinflammation theory in AD,respectively.Therefore,this article reviews the main functions of S100A8/S100A9 protein and its new research progress in AD-related pathogenesis,risk factors,prevention and treatment,in order to provide new research directions for the treatment of AD.

关 键 词：阿尔茨海默病 钙卫蛋白 S100A9 S100A8 

分 类 号：R749.16[医药卫生—神经病学与精神病学]