EphB3在肝癌组织中的表达及与患者临床病理特征关系的研究  

Expression of EphB3 in Hepatocellular Carcinoma and its Relationship with Clinical Characteristics of Patients

作　　者：王凤梅 张文华 樊平 董秀丽 陈多兆 白兆娟 Wang Fengmei;Zhang Wenhua;Fan Ping(Department of Hepatology Pathology,Wuwei Tumor Hospital,Wuwei,Gansu,733000,China)

机构地区：[1]甘肃省武威肿瘤医院肝病科,甘肃武威733000 [2]甘肃省武威肿瘤医院病理科,甘肃武威733000

出　　处：《黑龙江医学》2025年第4期413-415,共3页Heilongjiang Medical Journal

基　　金：甘肃省自然科学基金项目(20JR5RE635);甘肃省中西医结合肿瘤临床研究中心开放基金项目(zlzx2021-5);武威市科技局科技计划项目(WW2002054,WW2101113)。

摘　　要：目的:探讨产红细胞生成素的人肝细胞受体(Eph) B3在肝癌组织中的表达及与患者临床病理特征关系。方法:选取2018-2022年甘肃省武威肿瘤医院收治的44例肝细胞癌(HCC)患者作为肝癌组,其中,取行外科手术切除的30例患者的标本肿瘤组织作为观察组,取观察组患者癌旁(距癌组织边缘2 cm以上)正常肝脏组织作为对照组;选取同期样本医院收治的47例慢性乙型肝炎患者作为肝炎组。采用免疫组化方法检测各组患者EphB3表达,同时,收集HCC患者各项临床病理特征,分析其与EphB3表达的关系。结果:HCC患者肝癌组织EphB3表达与癌旁组织比较,差异有统计学意义(P<0.05);HCC患者肝癌组织EphB3表达与肝炎患者肝组织EphB3表达比较,差异有统计学意义(P<0.05)。肝癌患者EphB3表达与患者肝癌细胞分化程度呈负相关(r=-0.640,P<0.001);肝癌患者EphB3表达与患者年龄、AFP无相关性(P>0.05);是否合并乙肝、是否合并肝硬化、是否有肝外转移、是否单发的患者EphB3表达比较,差异无统计学意义(P>0.05)。结论:肝癌患者癌组织与癌旁组织、肝炎患者肝组织EphB3表达有明显差异,EphB3表达与肝癌细胞分化程度呈负相关,EphB3可能作为HCC患者预后判断的一个指标。Objective:To explore the expression of EphB3 in hepatocellular carcinoma and its relationship with clinical characteristics of patients.Methods:Collecting carcinoma of 44 HCC patients from Wuwei Cancer Hospital in Gansu Province from 2018 to 2022.Normal tissues adjacent to the cancer(more than 2 cm away from the tumor edge)were used as the control group.47 patients with chronic hepatitis B at the same time were collected as the hepatitis group.The liver tissues of these patients were taken through liver puncture biopsy.The expression of EphB3 in the tissues of each group were detected by immunohistochemistry.At the same time,the clinicopathological characteristics of HCC patients were collected to analyze their relationship with the expression of EphB3.Results:The expression of EphB3 in HCC was significantly different from the control group(P<0.05).The expression of EphB3 in HCC was significantly different from the hepatitis group(P<0.05).The expression of EphB3 was negatively correlated with the differentiation of liver cancer cells(r=-0.640,P<0.001).There was no correlation between the expression of EphB3 and age and AFP in patients with HCC(P>0.05).There was no significant difference in the expression of EphB3 in patients with hepatitis B,cirrhosis,extrahepatic metastasis or single disease(P>0.05).Conclusion:There is statistically signifiant difference in EphB3 between cancer tissue and adjacent tissue in patients with liver cancer and liver tissue in patients with hepatitis.The expression of EphB3 is negatively proportional to the differentiation degree of liver cancer cells.EphB3 can be used as an indicator of prognosis in patients with HCC.

关 键 词：肝细胞癌 产红细胞生成素的人肝细胞受体B3 临床病理特征 

分 类 号：R735.7[医药卫生—肿瘤]