The High Expression of EXOSC3 in OSCC is Associated with Poor Prognosis and Immune Infiltration  

作　　者：Yucunxi Liu Jianguo Liu 

机构地区：[1]Special Key Laboratory of Oral Diseases Research,School of Stomatology,Zunyi Medical University,Zunyi 563000,Guizhou Province,China

出　　处：《Proceedings of Anticancer Research》2025年第1期52-61,共10页抗癌研究

摘　　要：Oral squamous cell carcinoma(OSCC)is the most common malignant tumor in the oral and maxillofacial region,primarily affecting the tongue,gingiva,oral cavity,buccal mucosa,and floor of the mouth.It exhibits high rates of recurrence and metastasis,contributing to a poor prognosis for patients.Identifying molecular markers associated with OSCC holds significant value for advancing its diagnosis,treatment,and prognosis.Exosome Component 3(EXOSC3)is a protein-coding gene involved in the auto-degradation of E3 ubiquitin ligase COP 1 and rRNA processing in the nucleus and cytoplasmic sol.This gene plays a crucial role in diseases such as colon cancer and non-small cell lung cancer.Bioinformatics analysis revealed that EXOSC3 expression is significantly elevated in OSCC and is associated with poor patient prognosis.Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analyses indicate that EXOSC3 is strongly linked to the cytokine-cytokine receptor interaction,Toll-like receptor signaling pathway,and JAK-STAT signaling pathway.Moreover,immune infiltration analysis demonstrated a significant association between EXOSC3 expression and immune cell subset infiltration,as well as immune checkpoint expression,underscoring its importance in OSCC.However,further research is required to elucidate the specific role of EXOSC3 in OSCC diagnosis and treatment.A comprehensive investigation into the mechanisms of EXOSC3 in OSCC may reveal new potential targets for improving the diagnosis and treatment of this malignancy.

关 键 词：EXOSC3 Oral squamous cell carcinoma Immune microenvironment Immune checkpoint 

分 类 号：R73[医药卫生—肿瘤]