Advances in basic and translational research into nasopharyngeal carcinoma  

作　　者：Zhe Li Yupei Chen Jun Ma 

机构地区：[1]Department of Radiation Oncology,State Key Laboratory of Oncology in South China,Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy,Guangdong Provincial Clinical Research Center for Cancer,Sun Yat-sen University Cancer Center,Guangzhou,China

出　　处：《Oncology and Translational Medicine》2025年第1期10-16,共7页肿瘤学与转化医学(英文版)

基　　金：supported by the National Natural Science Foundation of China(no.81930072 and no.82172870 to J.Ma);by the Key-Area Research and Development Program of Guangdong Province(no.2019B020230002 to J.Ma).

摘　　要：According to the International Cancer Research Institute of the World Health Organization data,nasopharyngeal carcinoma(NPC)remains a significant health concern,particularly in regions such as Southeast Asia and southern China.Recently,substantial progress has been made in the field of basic and translational research on NPC,enhancing our understanding of the molecular mechanisms underlying the disease and paving the way for precise therapeutic approaches.This review summarizes the advances in NPC research,focusing on key areas that include radiotherapy and chemotherapy resistance and tumor metastasis,microenvironment,metabolism,microbiome,and biomarkers.Additionally,future research directions in NPC are discussed to provide valuable insights to advance the field further.

关 键 词：Nasopharyngeal carcinoma Treatment resistance Tumor biomarkers Tumor microenvironment 

分 类 号：R739.63[医药卫生—肿瘤]