地中海贫血与GDM及其对妊娠结局影响的研究进展  

Research progress of the influence of the thalassemia and gestational diabetes mellitus of pregnant women on their pregnancy outcomes

作　　者：龙兴江[1] 黄玉叶 覃娇凤 LONG Xingjiang;HUANG Yeyu;TAN Jiaofeng(Liuzhou People's Hospital,,Liuzhou,Guangxi Zhuang Autonomous Region,545000)

机构地区：[1]广西壮族自治区柳州市人民医院,545000

出　　处：《中国计划生育学杂志》2025年第2期491-495,共5页Chinese Journal of Family Planning

基　　金：柳州市科技计划项目(2022SB005)。

摘　　要：地中海贫血是一种临床常见的遗传性血液疾病,并以溶血性贫血和铁过载为临床特征。部分地中海贫血患者可显著增加合并糖耐量减退或糖尿病等代谢内分泌疾病风险。然而,关于地中海贫血是否增加妊娠期糖尿病发病风险却存在争议。目前,普遍认为地中海贫血对妊娠结局产生不利影响,妊娠期糖尿病作为另一种常见的导致不良妊娠结局的危险因素,地贫是否通过增加妊娠期糖尿病发生风险继而进一步负面影响妊娠结局值得思考。同时,如何有效监测地中海贫血合并妊娠期糖尿病对开展优生优育工作亦具有重要价值。本文将近年来地贫与妊娠期糖尿病及其妊娠结局影响的相关研究进行归纳总结,为指导临床实践提供借鉴。Thalassemia is a prevalent inherited blood disorder, with the clinical features of the hemolytic anemia and iron overload. Some patients with thalassemia significantly increase the risk of the metabolic and endocrine diseases, such as the impaired glucose tolerance or diabetes. However, there is controversy about whether the thalassemia of the pregnant women increases the risk of their gestational diabetes mellitus(GDM). At present, the thalassemia of the pregnant women has the adverse impact on their pregnancy outcomes universally. GDM is another common risk factor of the pregnant women leading to their adverse pregnancy outcomes. It is worth considering whether the thalassemia exacerbates the pregnancy outcomes by contributing to the risk of GDM occurrence of the pregnant women.

关 键 词：地中海贫血 妊娠期糖尿病 妊娠结局 研究进展 

分 类 号：R714.256[医药卫生—妇产科学] R714.254[医药卫生—临床医学]