支气管肺炎患儿治疗预后与血清细胞因子表达水平的相关性研究  

Correlation Study Between Treatment Prognosis and Serum Cytokine Expression Levels of Children with Bronchopneumonia

作　　者：邓艳桂 李葵[1] 张燕钦[1] 龚湛潮 DENG Yangui;LI Kui;ZHANG Yanqin;GONG Zhanchao(Guangzhou Huadu District People's Hospital,Guangzhou,Guangdong 510800)

机构地区：[1]广州市花都区人民医院,广东广州510800

出　　处：《智慧健康》2024年第35期98-101,106,共5页Smart Healthcare

基　　金：广州市花都区科技计划项目《支气管肺炎患儿治疗预后与血清细胞因子表达水平的相关性研究》(项目编号:23-HDWS-026)。

摘　　要：目的研究支气管肺炎患儿治疗预后与血清细胞因子表达水平的相关性。方法选取2023年4月—2024年5月在本院儿内科住院的60例支气管肺炎患儿,随访3个月,根据是否复发及再入院分为发生组和未发生组,记录两组一般资料、血清细胞因子表达水平,采用多因素Logistic回归分析影响支气管肺炎患儿预后的相关因素,并绘制ROC曲线,分析血清细胞因子表达水平与患儿预后的相关性。结果60例支气管患儿中出现复发及再入院30例,发生率为50.00%(30/60),未发生30例。复发及再入院组病情严重程度评分低于未发生组,差异有统计学意义(P<0.05)。复发及再入院组IL-6、IL-10水平低于未发生组,TNF-α、IFN-γ水平高于未发生组,差异有统计学意义(P<0.05)。多因素Logistic回归分析,显示TNF-α(OR=79.046,95%CI=2.270~2752.219)、IFN-γ(OR=9.821,95%CI=1.310~73.608)是复发及再入院发生的独立危险因素,病情严重程度评分(OR=0.812,95%CI=0.674~0.977)、IL-10(OR=0.764,95%CI=0.608~0.959)是复发及再入院发生的独立保护因素,尚不能认为IL-6对复发及再入院有独立影响(P>0.05)。以IL-10、TNF-α、IFN-γ为变量绘制ROC曲线,可知IL-10 AUC为0.737,TNF-αAUC为0.866,IFN-γAUC为0.711。结论支气管肺炎患儿复发及再入院发生率相对较高,与IL-10低表达及TNF-α、IFN-γ高表达相关。Objective To investigate correlation between treatment prognosis and serum cytokine expression levels of children with bronchopneumonia.Methods The paper collected 60 children with bronchopneumonia in pediatric department of our hospital from April 2023 to May 2024,with follow up of 3 months,and divided them into the incidence group and non incidence group based on condition of relapse and readmission.General information and serum cytokine expression levels were recorded for two groups.Factors affecting prognosis of children with bronchopneumonia were analyzed with multivariate logistic regression,correlation between serum cytokine expression levels and prognosis of children with bronchopneumonia was analyzed with ROC curve.Results Out of 60 cases,30 cases experienced recurrence and readmission,with incidence rate of 50.00%(30/60),while 30 cases showed no recurrence.The severity score of relapse and readmission group was lower than that of non-relapse group,and the difference was statistically significant(P<0.05).The levels of IL-6 and IL-10 in relapse and readmission group were lower than those in non-occurrence group,while the levels of TNF-αand IFN-γwere higher t han those in non-occurrence group,wit h statistical significance(P<0.05).Multivariate logistic regression analysis showed,TNF-α(OR=79.046,95%CI=2.270~2752.219)and IFN-γ(OR=9.821,95%CI=1.310~73.608)were independent risk factors of recurrence and readmission,while severity scores(OR=0.812,95%CI=0.674~0.977)and IL-10(OR=0.764,95%CI=0.608~0.959)were independent protective factors fo recurrence and readmission.It could not be concluded that IL-6 had independent effect on recurrence and readmission(P>0.05).By drawing ROC curves with IL-10,TNF-αand IFN-γas variables,it could be seen,AUC of IL-10 was 0.737,AUC of TNF-αwas 0.866 and AUC of IFN-γwas 0.711.Conclusion Children with bronchopneumonia has relatively high incidence of recurrence and readmission,which is correlated with low expression of IL-10 and high expression of TNF-αand IFN-γ.

关 键 词：支气管肺炎 预后 血清细胞因子表达水平 相关性 

分 类 号：R73[医药卫生—肿瘤]