双歧杆菌三联活菌对胃癌术后化疗患者免疫功能及肠道微生态的影响  

Effect of bifidobacterium triple viable bacteria on immune function and intestinal microecology in patients undergoing postoperative chemotherapy for gastric cancer

作　　者：武祖光 邓全军 孟小茹 侯仰坤 Wu Zu-guang;Deng Quan-jun;Meng Xiao-ru;Hou Yang-kun(Department of Gastroenterology,Special Medical Center of Armed Police Force,Tianjin 300162,China)

机构地区：[1]武警特色医学中心消化内科,天津300162

出　　处：《中国药物应用与监测》2025年第1期38-42,共5页Chinese Journal of Drug Application and Monitoring

摘　　要：目的分析双歧杆菌三联活菌胶囊对胃癌术后化疗患者免疫功能及肠道微生态的影响。方法选取2023年3月至2024年5月在武警特色医学中心诊治的102例胃癌术后化疗患者为研究对象,根据随机数字表法分为营养组和活菌组,各51例。营养组给予早期肠内营养治疗,活菌组在营养组基础上给予双歧杆菌三联活菌。比较两组炎症因子、免疫功能、肠道微生态菌群、疗效及不良反应发生情况。结果治疗后,活菌组白细胞介素1β(IL-1β)、转化生长因子β(TGF-β)、白细胞介素2(IL-2)、CD8^(+)、乳酸杆菌、双歧杆菌、粪肠球菌、拟杆菌水平[分别为(35.29±6.83)ng·mL^(-1)、(9.78±2.15)pg·mL^(-1)、(15.24±3.72)ng·mL^(-1)、(39.68±6.91)%、(5.12±1.36)Ig CFU·mL^(-1)、(4.95±1.02)Ig CFU·mL^(-1)、(4.37±1.15)Ig CFU·mL^(-1)、(7.89±2.14)Ig CFU·mL^(-1)]均低于营养组[分别为(50.17±8.46)ng·mL^(-1)、(21.69±3.84)pg·mL^(-1)、(30.16±4.65)ng·mL^(-1)、(50.17±6.85)%、(10.63±2.25)Ig CFU·mL^(-1)、(13.81±2.28)Ig CFU·mL^(-1)、(10.24±2.65)Ig CFU·mL^(-1)、(16.32±2.56)Ig CFU·mL^(-1)](t=11.237、19.327、17.839、7.699、14.967、25.332、14.511、18.043,均P<0.05)。治疗后,活菌组免疫球蛋白M(IgM)、免疫球蛋白G(IgG)、免疫球蛋白A(IgA)、CD4^(+)、CD4^(+)/CD8^(+)、大肠埃希菌水平[分别为(3.87±0.95)g·L^(-1)、(39.86±4.72)g·L^(-1)、(5.35±0.95)g·L^(-1)、(71.52±8.67)%、(1.80±0.32)、(25.76±3.49)Ig CFU·mL^(-1)]均高于营养组[分别为(2.56±0.43)g·L^(-1)、(25.15±3.59)g·L^(-1)、(3.98±0.82)g·L^(-1)、(59.34±9.21)%、(1.18±0.25)、(12.95±2.83)Ig CFU·mL^(-1)](t=8.971、17.715、7.796、6.877、10.904、20.360,均P<0.05)。活菌组治疗总有效率(82.35%,42/51)高于营养组(52.98%,27/51)(χ^(2)=10.079,P<0.05)。活菌组不良反应总发生率(3.92%,2/51)低于营养组(17.65%,9/51)(χ^(2)=4.993,P<0.05)。结论双歧杆菌三联活菌胶囊治疗胃癌术后化疗患者可降低炎症反应、不良反应发生�Objective To investigate the effect of bifidobacterium triple viable bacteria capsule on immune function and intestinal microecology of patients receiving postoperative chemotherapy for gastric cancer.Methods A total of 102 patients undergoing postoperative chemotherapy for gastric cancer in Special Medical Center of Armed Police Force from March 2023 to May 2024 were selected as the research subjects and dvided into the nutrition group and live bacteria group by using the random number table method,with 51 in each group.The patients in the nutrition group were given early enteral nutrition therapy while those in the live bacteria group were given bifidobacteria triple live bacteria based on early enteral nutrition therapy.The levels of the inflammatory factors,immune function indicators,intestinal microecological flora,curative effect and adverse reactions were compared between the two groups.Results After treatment,the levels of interleukin-1β(IL-1β),transforming growth factor-β(TGF-β),interleukin-2(IL-2),CD8^(+),Lactobacillus,Bifidobacterium,Enterococcus faecalis,and Bacteroides in the probiotics group((35.29±6.83)ng·mL^(-1),(9.78±2.15)pg·mL^(-1),(15.24±3.72)ng·mL^(-1),(39.68±6.91)%,(5.12±1.36)Ig CFU·mL^(-1),(4.95±1.02)Ig CFU·mL^(-1),(4.37±1.15)Ig CFU·mL^(-1),(7.89±2.14)Ig CFU·mL^(-1))were lower than those in the nutrition group((50.17±8.46)ng·mL^(-1),(21.69±3.84)pg·mL^(-1),(30.16±4.65)ng·mL^(-1),(50.17±6.85)%,(10.63±2.25)Ig CFU·mL^(-1),(13.81±2.28)Ig CFU·mL^(-1),(10.24±2.65)Ig CFU·mL^(-1),(16.32±2.56)Ig CFU·mL^(-1),respectively)(t=11.237,19.327,17.839,7.699,14.967,25.332,14.511,18.043,all P<0.05).The levels of immunoglobulin M(IgM),immunoglobulin G(IgG),immunoglobulin A(IgA),CD4^(+),CD4^(+)/CD8^(+),and Escherichia coli in the probiotics group((3.87±0.95)g·L^(-1),(39.86±4.72)g·L^(-1),(5.35±0.95)g·L^(-1),(71.52±8.67)%,(1.80±0.32),(25.76±3.49)Ig CFU·mL^(-1))were higher than those in the nutrition group((2.56±0.43)g·L^(-1),(25.15±3.59)g·L^(-1),(3.98±0.82)g·L^(-1),

关 键 词：双歧杆菌三联活菌 早期肠内营养 胃癌 化疗 免疫功能 肠道微生态 

分 类 号：R735.2[医药卫生—肿瘤]