Cx36在视网膜信号传导及近视进展中的作用研究进展  

Research progress on the role of Cx36 in retinal signal transduction and myopia progression

作　　者：张浩(综述) 郭俊国[1] 毕宏生(审校)[1,2] Zhang Hao;Guo Junguo;Bi Hongsheng(Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250002,China;Shandong Academy of Eye Disease Prevention and Therapy,Jinan 250002,China)

机构地区：[1]山东中医药大学附属眼科医院,济南250002 [2]山东省眼病防治研究院,济南250002

出　　处：《中华实验眼科杂志》2025年第2期169-173,共5页Chinese Journal Of Experimental Ophthalmology

基　　金：国家重点研发计划(2021YFC2702103、2019YFC1710205);山东省重点研发计划(2017GSF19110、2019GGH319001、2019GSF108252)。

摘　　要：视网膜是介导外界光信号转换为神经电信号的关键部位,缝隙连接蛋白(Cx)作为缝隙连接通道的基本结构和功能蛋白分子,在维持视网膜功能稳态中发挥重要作用。Cx36在视网膜信息传递以及生化因子调控等方面具有生理作用,并参与近视的形成过程。“局部视网膜-巩膜重塑”学说认为异常的视觉信息作用于视网膜,经视网膜色素上皮-脉络膜信号转导引起巩膜重塑,最终导致近视。探讨视网膜Cx36在视觉发育与近视形成中的作用及其机制,对近视防控具有重要的指导意义。本文就近年来关于Cx36在视网膜中的生理功能以及在近视发展的作用研究进行综述。The retina is a crucial site for mediating the conversion of external light signals into neural electrical signals.Connexin(Cx),as the basic structural and functional protein molecule of gap junction channels,plays an important role in maintaining the functional homeostasis of the retina.Cx36 has physiological functions in aspects such as retinal information transmission and biochemical factor regulation,and is involved in the formation of myopia.The"local retina-sclera remodeling"theory holds that abnormal visual information acts on the retina,causing sclera remodeling through retinal pigment epithelium-choroid signal transduction,and ultimately leading to myopia.Exploring the role and mechanism of retinal Cx36 in visual development and myopia formation is of great guiding significance for myopia prevention and control.This article reviews the research progress in the physiological functions of Cx36 in the retina and its role in myopia development in recent years.

关 键 词：视网膜 缝隙连接蛋白36 近视 信号传导 

分 类 号：R778.11[医药卫生—眼科]