腹腔镜剥除术对良性卵巢肿瘤患者卵巢功能及免疫功能的影响探讨  

Exploring the effects of laparoscopic excision on ovarian function and immune function in patients with benign ovarian tumors

作　　者：曹维维 CAO Wei-wei(Obstetrics and Gynecology Department,Nanjing Red Cross Hospital,Nanjing 210000,China)

机构地区：[1]南京市红十字医院妇产科,210000

出　　处：《中国现代药物应用》2025年第2期5-9,共5页Chinese Journal of Modern Drug Application

摘　　要：目的 探讨腹腔镜剥除术对良性卵巢肿瘤患者卵巢功能及免疫功能的影响。方法 回顾性分析84例良性卵巢肿瘤患者的临床资料,根据手术治疗方式差异分为传统手术组(n=32)与腹腔镜组(n=52)。传统手术组的治疗方法为传统开腹手术,腹腔镜组的治疗方法为腹腔镜肿瘤剥除术。比较两组手术治疗指标、并发症发生率及手术前后炎性因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-10(IL-10)]水平、卵巢功能[雌二醇(E2)、促黄体生成素(LH)、卵泡刺激素(FSH)]、免疫功能[免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、免疫球蛋白M(IgM)]。结果 相较于传统手术组的(122.38±12.75)ml、(2.15±0.59)d、(6.50±1.12)d、(53.55±10.69)min,腹腔镜组术中出血量(75.70±8.90)ml更少,术后胃肠道功能恢复时间(1.68±0.36)d与住院时间(4.80±0.75)d更短,手术治疗时间(64.20±8.86)min更长(P<0.05)。腹腔镜组术后72 h的TNF-α(6.12±1.08)ng/L、IL-6(23.80±4.43)ng/L、IL-10(90.95±20.21)ng/L均较传统手术组的(9.46±1.87)、(32.60±6.38)、(107.25±22.79)ng/L更低(P<0.05)。腹腔镜组术后72 h的FSH(9.70±1.88)U/L、LH(10.03±1.57)U/L低于传统手术组的(13.88±2.35)、(14.52±1.88)U/L,E2(98.90±12.10)pmol/L高于传统手术组的(76.74±9.69)pmol/L(P<0.05)。两组术后72 h的IgG水平均低于术前,腹腔镜组术后72 h的IgG(9.98±1.90)g/L高于传统手术组的(8.35±1.75)g/L(P<0.05)。两组术前和术后72 h的IgA、IgM水平组间组内比较均无统计学意义(P>0.05)。腹腔镜组并发症发生率11.54%低于传统手术组的37.50%(P<0.05)。结论 良性卵巢肿瘤以腹腔镜剥除术治疗,可减轻手术创伤,降低对机体卵巢功能、免疫功能的影响,且并发症相对较少,安全性高。Objective To explore the effects of laparoscopic excision on ovarian function and immune function in patients with benign ovarian tumors.Methods A retrospective analysis was conducted on the clinical data of 84 patients with benign ovarian tumors.According to the differences in surgical treatment methods,they were divided into a traditional surgery group(n=32) and a laparoscopic group(n=52).The traditional surgery group was treated with traditional open surgery,and the laparoscopic group was treated with laparoscopic excision.Both groups were compared in terms of surgical treatment indicators,complication rate,inflammatory factor[ tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),interleukin-10(IL-10)] levels,ovarian function[ estradiol(E2),luteinizing hormone(LH),follicle-stimulating hormone(FSH)],immune function [immunoglobulin A(IgA),immunoglobulin G(IgG),immunoglobulin M(IgM)] before and after surgery.Results Compared with(122.38±12.75) ml,(2.15±0.59) d,(6.50±1.12) d,(53.55±10.69) min in the traditional surgery group,the intraoperative blood loss(75.70±8.90) ml in the laparoscopic group was less,and the postoperative gastrointestinal function recovery time(1.68±0.36) d and hospitalization time(4.80±0.75) d were shorter,and the surgical treatment time(64.20±8.86) min was longer(P<0.05).At 72 h after surgery,the laparoscopic group had TNF-α of(6.12±1.08) ng/L,IL-6 of(23.80±4.43) ng/L and IL-10 of(90.95±20.21) ng/L,which were lower than(9.46±1.87),(32.60±6.38) and(107.25±22.79) ng/L in the traditional surgery group(P<0.05).At 72 h after surgery,the laparoscopic group had FSH of(9.70±1.88) U/L and LH of(10.03±1.57) U/L,which were lower than(13.88±2.35) and(14.52±1.88) U/L in the traditional surgery group;the laparoscopic group had higher E2 of(98.90±12.10) pmol/L than(76.74±9.69) pmol/L in the traditional surgery group(P<0.05).At 72 h after surgery,IgG level in both groups was lower than that before surgery,and IgG level of(9.98±1.90) g/L in the laparoscopic group were higher than(8.35±1

关 键 词：良性卵巢肿瘤 腹腔镜剥除术 炎性反应 卵巢功能 免疫功能 并发症 

分 类 号：R737.31[医药卫生—肿瘤]