Multidimensional Role of Amino Acid Metabolism in Immune Regulation:From Molecular Mechanisms to Therapeutic Strategies  

作　　者：QIN Changjuan YANG Guanqing WEI Qi XIN Hua DING Jianxun CHEN Xuesi 

机构地区：[1]Key Laboratory of Polymer Ecomaterials,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun,130022,P.R.China [2]Department of Thoracic Surgery,China-Japan Union Hospital of Jilin University,Changchun,130033,P.R.China [3]School of Applied Chemistry and Engineering,University of Science and Technology of China,Hefei,230026,P.R.China

出　　处：《Chemical Research in Chinese Universities》2025年第1期1-14,共14页高等学校化学研究(英文版)

基　　金：supported by the National Natural Science Foundation of China(Nos.U23A20591,52273158,and 52203200);the Science and Technology Development Program of Jilin Province,China(Nos.20240101002JJ,20240404010ZP,and YDZJ202402077CXJD);the Youth Talents Promotion Project of Jilin Province,China(No.Y2023066).

摘　　要：Immune cells are essential components of the human immune system,playing a critical role in maintaining human health and defending against diseases.Changes in nutritional metabolism influence the activation,proliferation,apoptosis,differentiation direction,and other behaviors of immune cells,affecting immune function.Amino acids,fundamental nutrients in all living organisms,are crucial for maintaining redox balance,regulating energy,supporting biosynthesis,and preserving homeostasis.The availability of amino acids influences the behaviors and functions of immune cells significantly.Therefore,understanding the intricate relationship between amino acid metabolism and immune cell behavior leads to identifying unique therapeutic targets and improving clinical outcomes.The review summarizes the impact of different types of amino acid metabolism on the behaviors of dendritic cells and T cells,hoping to provide a valuable reference for researchers and clinicians in related fields.

关 键 词：Amino acid METABOLISM Dendritic cell T cell IMMUNOMODULATION 

分 类 号：O62[理学—有机化学]