非小细胞肺癌动态增强CT特征与病灶组织TTF-1、CK5/6表达的关系  

Relationship between dynamic enhanced CT features and the expression of TTF-1 and CK5/6 in lesion tissues of non-small cell lung cancer

作　　者：孟锦 张冰凌[1] 马啸天 李卫星[1] MENG Jin;ZHANG Bing-ling;MA Xiao-tian;LI Wei-xing(CT Department,Xinxiang Central Hospital,Xinxiang Henan 453000,China)

机构地区：[1]新乡市中心医院CT室,河南新乡453000

出　　处：《中国临床医学影像杂志》2025年第2期99-103,共5页Journal of China Clinic Medical Imaging

基　　金：河南省医学科技攻关计划项目(LHGJ20230879)。

摘　　要：目的:探讨非小细胞肺癌(NSCLC)患者动态增强CT检查特征与病灶组织中甲状腺转录因子1(TTF-1)、细胞角蛋白5/6(CK5/6)表达的关系。方法:选取我院2021年1月—2023年6月经病理学检查确诊的138例NSCLC患者开展临床研究,分别对比不同TTF-1、CK5/6蛋白表达水平患者的动态增强CT特征及扫描参数。结果:138例NSCLC患者,其中TTF-1蛋白阳性表达92例(66.70%)、CK5/6蛋白阳性表达73例(52.90%);CK5/6蛋白阳性表达的NSCLC患者的毛刺征阳性率、血管集束征检出率、胸膜侵犯率、淋巴结转移率均显著高于CK5/6蛋白阴性表达的NSCLC患者(P<0.05);CK5/6蛋白阳性患者灌注值、强化峰值(PH)值均高于CK5/6蛋白阴性患者(P<0.05)。结论:TTF-1蛋白表达与NSCLC患者动态增强CT特征及参数关系不明显,CK5/6蛋白在NSCLC疾病发展中起到重要作用,并且与患者动态增强CT特征及参数相关,临床上可以作为判断辅助手段帮助评估肿瘤发展程度及临床诊断。Objective:To explore the relationship between dynamic enhanced CT features and the expression of thyroid transcription factor 1(TTF-1)and cytokeratin 5/6(CK5/6)in lesion tissues of non-small cell lung cancer(NSCLC)patients.Methods:A total of 138 patients with NSCLC diagnosed by pathological examination in Xinxiang Central Hospital from January 2021 to June 2023 were selected for clinical study.Dynamic enhanced CT features and scanning parameters of patients with different TTF-1 and CK5/6 protein expression levels were compared,respectively.Results:Of 138 NSCLC patients,92(66.70%)had positive expression of TTF-1 protein and 73(52.90%)had positive expression of CK5/6 protein.The burr positive rate,vascular cluster sign detection rate,pleural invasion rate and lymph node metastasis rate of NSCLC patients with CK5/6protein positive expression were significantly higher than those with CK5/6 protein negative expression(P<0.05).The perfusion value and peak height(PH)value of CK5/6 protein positive patients were higher than those of CK5/6 protein negative patients(P<0.05).Conclusion:There is no significant correlation between the expression of TTF-1 protein and the dynamic enhanced CT features and parameters in NSCLC patients.CK5/6 protein plays an important role in the development of NSCLC disease and is related to the dynamic enhanced CT features and parameters of patients.In clinical practice,it can be used as an auxiliary means to evaluate the degree of tumor development and clinical diagnosis.

关 键 词：癌 非小细胞肺 体层摄影术 螺旋计算机 

分 类 号：R734.2[医药卫生—肿瘤] R814.42[医药卫生—临床医学]