催产素受体rs2254298基因多态性与广泛性焦虑障碍治疗疗效之间的相关性研究  

Association between rs2254298 gene polymorphism of oxytocin receptor and treatment response of generalized anxiety disorder

作　　者：薛亮 倪红芬[1] 戴红[1] 陈萍 王露 沈鑫华[1] XUE Liang;NI Hong-fen;DAI Hong;CHEN Ping;WANG Lu;SHEN Xin-hua(Huzhou Third Municipal Hospital,Huzhou 313000,China)

机构地区：[1]浙江湖州市第三人民医院,313000

出　　处：《临床精神医学杂志》2025年第1期16-20,共5页Journal of Clinical Psychiatry

基　　金：湖州市科技局基金项目(2020GYB42)。

摘　　要：目的:探讨催产素浓度及rs2254298受体基因型与广泛性焦虑障碍(general anxiety disorder,GAD)患者临床疗效间的相关性。方法:纳入2021年8月至2023年6月湖州市第三人民医院就诊的88例GAD患者为病例组,应用汉密尔顿焦虑量表(Hamilton anxiety scale,HAMA)在基线及治疗第2、4、8周末进行疗效评价;按照HAMA减分率分为有效组和无效组;92名健康人为对照组在基线水平用HAMA进行评估;所有参与者在基线水平检测催产素浓度及rs2254298基因型。对催产素浓度和rs2254298受体基因型与GAD疗效之间进行相关性分析。结果:病例组催产素水平高于对照组,差异有统计学意义(P=0.006);病例组治疗第8周有效组和无效组基因型分布差异有统计学意义(P=0.049),2、4周差异均无统计学意义;回归分析显示催产素浓度及rs2254298基因型不是预测GAD疗效的重要因素。结论:GAD患者存在血清催产素浓度异常,rs2254298基因型与GAD的治疗疗效存在相关关系。Objective:To investigate the correlation between oxytocin concentration,rs2254298 receptor genotype,and treatment response in patients with generalized anxiety disorder(GAD).Method:A total of 88 GAD patients who visited Huzhou Third Municipal Hospital from August 2021 to June 2023 were included in the case group.Hamilton anxiety scale(HAMA)was used to evaluate the response at baseline and at the 2nd,4th and 8th week after treatment.They were divided into the responder group and the non-responder group according to HAMA reduction rate.A control group of 92 healthy subjects was evaluated at baseline with HAMA.Oxytocin levels and rs2254298 genotypes were measured at baseline for all participants.The correlation between oxytocin concentration and rs2254298 receptor genotype and GAD efficacy was analyzed.Results:The level of oxytocin in case group was higher than that in the control group,the difference was statistically significant(P=0.006).At the 8th week of treatment,there was a statistically significant difference in genotype distribution between the responder group and the non-responder group(P=0.049),but no statistically significant difference at the 2nd and 4th week.Regression analysis showed that oxytocin concentration and rs2254298 genotype were not important factors in predicting the efficacy of GAD.Conclusion:GAD patients exhibit abnormal plasma oxytocin concentration,and the rs2254298 genotype is associated with the treatment response of GAD.

关 键 词：广泛性焦虑障碍 催产素 rs2254298受体基因型 

分 类 号：R749.7[医药卫生—神经病学与精神病学]