精神康复干预对精神分裂症患者的作用  

Role of psychiatric rehabilitation interventions for patients with schizophrenia

作　　者：王玉城 吴荣琴 徐璐 黄岭 张岩 周燕 杜向东[3] WANG Yu-cheng;WU Rong-qin;XU Lu;HUANG Ling;ZHANG Yan;ZHOU Yan;DU Xiang-dong(Department of Pshchiatry,Shanghai Jingan Mental Health Center,Shanghai 200436,China)

机构地区：[1]上海市静安区精神卫生中心一病区,200436 [2]上海市长宁区精神卫生中心(华东师范大学附属精神卫生中心)医技科 [3]苏州大学附属广济医院精神科

出　　处：《临床精神医学杂志》2025年第1期59-62,共4页Journal of Clinical Psychiatry

摘　　要：目的:探讨精神康复干预(psychiatric rehabilitation intervention,PRI)及错误相关电位(error related negativity,ERN)联合应用在精神分裂症中的作用。方法:选取精神分裂症患者148例,应用随机数字表法,将患者组分成研究组和对照组各74例,研究组采用PRI和对照组采用普通支持,疗效评估者盲法,ERN对精神分裂症认知功能进行监测。结果:实施PRI后,研究组的简明精神病评定量表(brief psychiatric rating scale,BPRS)自知力与社会功能缺陷测定(social disability screening schedule,SDSS)和治疗依从性(medication adherence rating scale,MARS)问卷增分值均高于对照组。实施PRI后,研究组家属的精神症状自评量表(symptom check list,SCL-90)各因子减分值高于对照组。研究组康复后,ERN检测中的潜伏期和波幅随着改善[Cz电极潜伏期干预前(47.5±13.2),干预3个月(40.9±14.1),t=4.195,P<0.01,Cz电极波幅干预前(4.4±2.1),干预3个月(8.6±2.4),t=4.195,P<0.01]。同时Pz电极改变也是同一趋势。与此同步所做的对照组上述指标差异无统计学意义(P均>0.05)。结论:PRI干预有利于患者康复,ERN可辅助用于康复测评。Objective:To explore the combined application of psychological rehabilitation intervention(PRI)and error related negativity(ERN)in schizophrenia.Method:148 patients with schizophrenia were selected.Using the random number table method,the patient group was divided into a study group and a control group,with 74 cases in each group.The study group received PRI and the control group received general support.The efficacy evaluator was blinded,and ERN was used to monitor cognitive function in schizophrenia.Results:After implementing PRI,the study group's brief psychiatric rating scale(BPRS),social disability screening schedule(SDSS),and medication adherence rating scale(MARS)questionnaire scores were higher than those of the control group.After implementing PRI,the reduced scores of each factor on the symptom check list(SCL-90)of the study group's family members were higher than those of the control group.As the research group recovered,the latency and amplitude of ERN detection improved[Pre intervention latency of Cz electrode(47.5±13.2),intervention 3 months(40.9±14.1),t=4.195,P<0.01,Pre intervention amplitude of Cz electrode(4.4±2.1),intervention 3 months(8.6±2.4),t=4.195,P<0.01].At the same time,changes in the Pz electrode showed the same trend.The differences in the above indicators between the study group and the control group were not significant(all P>0.05).Conclusion:PRI intervention is beneficial for patient recovery,and ERN can be used as an adjunct for rehabilitation assessment.

关 键 词：精神康复干预 错误相关电位 精神分裂症 认知功能 

分 类 号：R749.3[医药卫生—神经病学与精神病学]