An in-depth understanding of the role and mechanisms of T cells in immune organ aging and age-related diseases  

作　　者：Yudai Xu Zijian Wang Shumin Li Jun Su Lijuan Gao Junwen Ou Zhanyi Lin Oscar Junhong Luo Chanchan Xiao Guobing Chen 

机构地区：[1]Department of Microbiology and Immunology,School of Medicine,Institute of Geriatric Immunology,School of Medicine,Jinan University,Guangzhou 510632,China [2]Key Laboratory of Viral Pathogenesis&Infection Prevention and Control(Jinan University),Ministry of Education,Guangzhou 510632,China [3]Guangdong-Hong Kong-Macao Great Bay Area Geroscience Joint Laboratory,School of Medicine,Jinan University,Guangzhou 510632,China [4]First Affiliated Hospital,Jinan University,Guangzhou 510630,China [5]Anti Aging Medical Center,Clifford Hospital,Guangzhou 511495,China [6]Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences),Southern Medical University,Guangzhou 510080,China [7]Department of Systems Biomedical Sciences,School of Medicine,Jinan University,Guangzhou 510632,China [8]The Sixth Affiliated Hospital of Jinan University(Dongguan Eastern Central Hospital),Jinan University,Dongguan 523000,China [9]Zhuhai Institute of Jinan University,Jinan University,Zhuhai 519070,China

出　　处：《Science China(Life Sciences)》2025年第2期328-353,共26页中国科学(生命科学英文版)

基　　金：supported by the R&D Program of Guangzhou Laboratory(SRPG22-006);the National Natural Science Cross Disciplinary Major Research Program(92374203);the National Natural Science Foundation of China(92169102);the GuangDong Basic and Applied Basic Research Foundation(2022B1515120043),the Guangdong Basic and Applied Basic Research Foundation(2023A1515140117);the Open Project Fund of Guangdong Provincial People's Hospital(YKY-KF202208);the Key R&D Program Key Special Projects for International Science and Technology Innovation Cooperation between Governments(2023YFE0118700);the Fundamental Research Funds for the Central Universities(21623406);the Fellowship of the China Postdoctoral Science Foundation(2023TQ0136,2023M741379);the Open Research Project of the Key Laboratory of Viral Pathogenesis&Infection Prevention and Control of the Ministry of Education(2023VPPC-R08)。

摘　　要：T cells play a critical and irreplaceable role in maintaining overall health.However,their functions undergo alterations as individuals age.It is of utmost importance to comprehend the specific characteristics of T-cell aging,as this knowledge is crucial for gaining deeper insights into the pathogenesis of aging-related diseases and developing effective therapeutic strategies.In this review,we have thoroughly examined the existing studies on the characteristics of immune organ aging.Furthermore,we elucidated the changes and potential mechanisms that occur in T cells during the aging process.Additionally,we have discussed the latest research advancements pertaining to T-cell agingrelated diseases.These findings provide a fresh perspective for the study of T cells in the context of aging.

关 键 词：T cell AGING immune organ age-related diseases 

分 类 号：R73[医药卫生—肿瘤]