预防性使用抗生素时机对高甘油三酯血症性重症急性胰腺炎患者预后的影响  

Influence of timing of prophylactic use of antibiotics on prognosis of patients with hypertriglyceridemic severe acute pancreatitis

作　　者：刘敬波[1] 钟强 Liu Jing-bo;Zhong Qiang(Department of Emergency Surgery,The Affiliated Hospital of Xinyang Vocational and Technical College,Xinyang 464000,Henan,China)

机构地区：[1]信阳职业技术学院附属医院急诊外科,河南信阳464000

出　　处：《四川生理科学杂志》2025年第2期295-297,416,共4页

摘　　要：目的:探讨预防性使用抗生素时机对高甘油三酯血症性重症急性胰腺炎(HTG-SAP)患者的预后的影响。方法:回顾分析2021年1月至2024年2月本院102例HTG-SAP患者,分为早期组(入院72 h内使用抗生素,n=50)和延迟组(入院72 h后使用,n=52)。比较两组患者血清炎症因子水平、感染情况及临床指标。结果:停药后,两组患者血清炎症因子水平均下降,且延迟组患者血清炎症因子水平显著低于延迟组(P<0.05),早期预防组患者住院期间感染发生率、全因死亡率无显著性差异(P>0.05),重症监护室时间、总住院时间显著低于早期组(P<0.05)。结论:入院72h后预防性使用抗生素能够有效减轻高甘油三酯血症性重症急性胰腺炎患者的炎症反应,降低院内感染率,缩短患者住院时间。Objective:To investigate the influence of timing of prophylactic use of antibiotics on the prognosis of patients with hypertriglyceridemic severe acute pancreatitis(HTG-SAP).Methods:Totally 102 patients with HTG-SAP in the hospital were retrospectively analyzed from January 2021 to February 2024,and were divided into early group(applying antibiotics within 72 hours of admission,n=50)and delayed group(applying antibiotics after 72 hours of admission,n=52).Serum inflammatory factors,infection status and clinical indicators were compared between groups.Results:After drug withdrawal,serum inflammatory factors levels were decreased in both groups,and the levels in delayed group were significantly lower than those in delayed group(P<0.05).There were no obvious differences in the incidence rate of infection during hospitalization and all-cause mortality between early group and delayed group(P>0.05),and the intensive care unit time and total hospitalization time were significantly shorter than those in early group(P<0.05).Conclusion:Prophylactic use of antibiotics after 72 hours of admission can effectively relieve the inflammatory response of patients with hypertriglyceridemic severe acute pancreatitis,reduce the nosocomial infection rate and shorten the hospitalization time of patients.

关 键 词：抗生素 高甘油三酯血症性重症急性胰腺炎 预后 炎症因子 

分 类 号：R47[医药卫生—护理学]