氨磺必利治疗精神分裂症的效果及对患者心电图的影响  

Effect of amisulpride in treating schizophrenia and on electrocardiogram

作　　者：郭红杰 肖丽 Guo Hong-jie;Xiao Li(Department of Psychiatry,Sanmenxia Rehabilitation Hospital,Sanmenxia 472000,Henan,China)

机构地区：[1]三门峡市康复医院精神科,河南三门峡472000

出　　处：《四川生理科学杂志》2025年第2期301-303,共3页

摘　　要：目的:探讨氨磺必利治疗精神分裂症的效果及对患者心电图的影响。方法:选取2020年1月至2024年3月三门峡市康复医院收治的63例精神分裂症患者作为研究对象,以随机数字表法分为对照组(n=31)和观察组(n=32),分别口服利培酮片(1 mg·d^(-1),2 w后剂量调整为4~6 mg·d^(-1);每日1次)以及氨磺必利片(200 mg·d^(-1),2 w后调整剂量为400~1200 mg·d^(-1);分2次口服)治疗2 m。治疗2 m后比较两组疗效,治疗前及治疗1、2 m后以动态心电图记录器监测心电图指标,以阳性与阴性症状量表(Positive and negative syndrome scale,PANSS)评估精神症状改善情况,并统计治疗期间的不良反应。结果:治疗2 m后,观察组临床总有效率高于对照组;与治疗前相比,治疗1 m及2 m后,各治疗组的QT间期均明显增加,其中对照组更为显著;与治疗前相比,治疗2 m后,各治疗组的阳性症状、阴性症状及一般精神病理症状评分及PANSS总分均明显降低,其中观察组更为显著(P<0.05)。治疗期间两组不良反应发生率无显著差异(P>0.05)。结论:与利培酮比,氨磺必利治疗精神分裂症疗效更好、对心电图影响更小,且对精神症状具有显著改善作用,安全性良好。Objective:To explore the effect of amisulpride in the treatment of schizophrenia and its influence on the electrocardiogram of patients.Methods:A total of 63 patients with schizophrenia admitted to Sanmenxia Rehabilitation Hospital from January 2020 to March 2024 were selected as the research objects.They were divided into the control group(n=31)and the observation group(n=32)by random number table method.The control group was treated with risperidone tablets(1 mg·day^(-1),and the dose was adjusted to 4~6 mg·day^(-1) after 2 weeks;once a day),and the observation group was treated with amisulpride tablets(200 mg·day^(-1),the dose was adjusted to 400~1200 mg·day^(-1) after 2 weeks;Bid).Both groups were treated for 2 months.After 2 months of treatment,the curative effects of the two groups were compared.The electrocardiogram indexes were monitored by a dynamic electrocardiogram recorder before treatment and after 1 and 2 months of treatment.The positive and negative syndrome scale(PANSS)was used to evaluate the improvement of mental symptoms before treatment and after 2 months of treatment.Adverse reactions were counted during treatment.Results:After 2 months of treatment,the total clinical effective rate in the observation group was higher than that in the control group.Compared with before treatment,the QT interval of each treatment group increased significantly after 1 month and 2 months treatment,with the control group showing a more significant increase.Compared with before treatment,the scores of positive symptoms,negative symptoms,general psychopathological symptoms,and PANSS total score in each treatment group significantly decreased after 2 months of treatment,with the observation group showing a more significant decrease(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups during the treatment period(P>0.05).Conclusion:Compared with risperidone,amisulpride has better efficacy in treating schizophrenia,less impact on electrocardiogram,and significant i

关 键 词：精神分裂症 氨磺必利 心电图 QT间期 精神症状 

分 类 号：R749.3[医药卫生—神经病学与精神病学]