结直肠癌组织P53、TIGIT、PD-L1表达及其意义分析  

Expression and significance of P53,TIGIT and PD-L1 in colorectal cancer

作　　者：买春阳[1] 张建 闫振宇[1] Mai Chun-yang;Zhang Jian;Yan Zhen-yu(Department of Pathology,Nanyang Central Hospital,Nanyang 473001,Henan,China)

机构地区：[1]南阳市中心医院病理科,河南南阳473001

出　　处：《四川生理科学杂志》2025年第2期328-331,378,共5页

摘　　要：目的:探讨结直肠癌患者癌组织中P53、T细胞免疫球蛋白和ITIM结构域(T-cell immunoreceptor with immunoglobulin and ITIM domains,TIGIT)、细胞程序性死亡-配体1(Programmed cell death-ligand 1,PD-L1)的表达。方法:回顾性纳入2022年12月至2023年12月到我院就诊的120例结直肠癌患者,收集研究对象的癌组织及其癌旁组织,检测并比较癌组织、癌旁组织中P53、TIGIT、PD-L1表达情况。结果:相较于癌旁组织,癌组织中P53、TIGIT、PD-L1阳性表达率较高(P<0.05)。相较于中高分化、肿瘤-结节-转移分期(Tumor,nodes,metastasis classification,TNM)分期为Ⅰ~Ⅱ期、淋巴结未转移、肿瘤直径≤5 cm的结直肠癌患者,低分化、TNM分期为Ⅲ~Ⅳ期、淋巴结转移、肿瘤直径>5 cm的结直肠癌患者组织P53、TIGIT、PD-L1阳性表达率均较高(P<0.05)。结直肠癌组织P53与TIGIT、PD-L1呈正相关,TIGIT与PD-L1呈正相关(P<0.05)。结论:在结直肠癌组织中P53、TIGIT、PD-L1呈高表达,且与疾病分期、分化程度等存在关系。Objective:To investigate the expression of P53,T-cell immunoreceptor with immunoglobulin and ITIM domains(TIGIT)and programmed cell death-ligand 1(PD-L1)in colorectal cancer tissues.Methods:120 patients with colorectal cancer in our hospital from December 2022 to December 2023 were retrospectively enrolled.The cancer tissues of the subjects and their adjacent tissues were collected,the expressions of P53,TIGIT and PD-L1 in cancer tissues and adjacent tissues were detected and compared.Results:Compared with the adjacent tissues,the positive expression rates of P53,TIGIT and PD-L1 in cancer tissues were higher(P<0.05).Compared with colorectal cancer patients with moderate and high differentiation,tumor,nodes,metastasis classification(TNM)stageⅠ~Ⅱ,lymph node metastasis or tumor diameter≤5 cm,the positive expression rates of P53,TIGIT and PD-L1 were higher in patients with low differentiation,TNM stageⅢ~Ⅳ,lymph node metastasis or tumor diameter>5 cm.P53 was positively correlated with TIGIT and PD-L1,and TIGIT was positively correlated with PD-L1(P<0.05).Conclusion:P53,TIGIT and PD-L1 are highly expressed in colorectal cancer tissues,which are related to the stage and differentiation of the disease.

关 键 词：结直肠癌 细胞程序性死亡-配体1 T细胞免疫球蛋白和ITIM结构域 免疫组织化学染色法 P53 

分 类 号：R735.34[医药卫生—肿瘤]