依达拉奉右莰醇联合阿托伐他汀治疗进展性急性脑梗死患者的临床研究  

Clinical study of combined edaravone dexbomeol and atorvastatin on progressive acute cerebral infarction patients

作　　者：叶长春 Ye Chang-chun(Department of Neurology,Qianshan People's Hospital,Shangrao 334500,Jiangxi,China)

机构地区：[1]铅山县人民医院神经内科,江西上饶334500

出　　处：《四川生理科学杂志》2025年第2期392-394,共3页

摘　　要：目的:探究依达拉奉右莰醇联合阿托伐他汀治疗进展性急性脑梗死(Acute progressive cerebral infarction,APCI)的临床效果。方法:根据是否使用依拉达奉右莰醇将本院2022年1月至2024年6月收治的60例APCI患者分为观察组(n=26)和对照组(n=34),分别进行基础治疗联合口服阿托伐他汀(10 mg,Qd)或静脉注射依达拉奉右莰醇(15 mL,Bid)治疗。治疗14 d后,采用SF-800凝血分析仪检测凝血指标、采用彩色经颅多普勒超声检测脑血流动力学,采用比色法检测血清自由基相关指标,并记录治疗期间不良反应。结果:治疗后,观察组活化部分凝血活酶时间(Activated partial thromboplastin time,APTT)、凝血酶时间(Thrombin time,TT)、凝血酶原时间(Prothrombin time,PT)、脑血管最小血流量(Minimum cerebral blood flow,Q_(min))、最小血流速度(Minimum blood flow velocity,V_(min))、平均血流速度(Mean blood flow velocity,V_(mean))、活性氧簇(Reactive oxygen species,ROS)水平均显著高于对照组(P<0.05),氧化物歧化酶(Superoxide dismutase,SOD)水平显著高于对照组(P<0.05),两组不良反应比较无显著性差异(P>0.05)。结论:依达拉奉右莰醇联合阿托伐他汀治疗APCI患者疗效显著,能有效改善患者的凝血状态,增加脑血流量,降低氧化应激反应,临床安全性良好。Objective:To investigate the clinical effect of edaravone dexbomeol combined with atorvastatin in the treatment of patients with acute progressive cerebral infarction(APCI).Methods:Sixty patients with APCI who were admitted to the hospital from January 2022 to June 2024 were divided into the observation group(n=26)and the control group(n=34).The control group was given basic treatment combined with oral administration of atorvastatin(10 mg,Qd).On this basis,the observation group was treated with intravenous injection of edaravone dexbomeol(15 mL,Bid).After 14 days of treatment,an SF-800 blood coagulation analyzer was used to detect coagulation indicators.Transcranial color Doppler ultrasound was used to detect cerebral hemodynamics,and colorimetry was used to detect serum free radical-related indicators.Adverse reactions that occurred during treatment were recorded.Results:After treatment,activated partial thromboplastin time(APTT),thrombin time(TT),prothrombin time(PT),minimum cerebral blood flow(Q_(min)),minimum blood flow velocity(V_(min)),mean blood flow velocity(V_(mean)),and reactive oxygen species(ROS)levels in the observation group were much higher than those in the control group(P<0.05).The level of superoxide dismutase(SOD)was much higher than that in the control group(P<0.05).Adverse reactions in the two groups were comparable(P>0.05).Conclusion:The combined treatment with edaravone dexbomeol and atorvastatin can effectively improve coagulation status,increase cerebral blood flow,and reduce oxidative stress reactions in patients with APCI,with good clinical safety.

关 键 词：进展性急性脑梗死 依拉达奉右莰醇 凝血状态 脑血流动力学 

分 类 号：R743.33[医药卫生—神经病学与精神病学]