雷珠单抗联合眼底激光对糖尿病黄斑水肿患者视力水平的影响  

Effect of Ranibizumab Combined with Fundus Laser on Visual Acuity in Patients with Diabetic Macular Edema

作　　者：董宁宁 张海[2] 王建祥[2] DONG Ningning;ZHANG Hai;WANG Jianxiang(Department of Ophthalmology,Shouguang People's Hospital,Shouguang 262700,Shandong,China;Department of Emergency,Shouguang People's Hospital,Shouguang 262700,Shandong,China)

机构地区：[1]寿光市人民医院眼科,山东寿光262700 [2]寿光市人民医院急诊科,山东寿光262700

出　　处：《糖尿病新世界》2024年第21期181-184,共4页Diabetes New World

摘　　要：目的探讨眼底激光联合雷珠单抗治疗糖尿病黄斑水肿患者的疗效及对视力水平的影响。方法选择2023年5月—2024年2月寿光市人民医院收治的94例糖尿病黄斑水肿患者,按治疗方法不同分为两组,各47例。对照组给予眼底激光干预,观察组在对照组基础上联合雷珠单抗治疗。比较两组最佳矫正视力、黄斑区水肿容积、黄斑中心凹厚度(central macular thickness,CMT)、眼压、炎症因子水平及并发症发生率。结果干预后,两组最佳矫正视力均提高,黄斑区水肿容积、CMT及眼压水平均降低,且观察组最佳矫正视力高于对照组,黄斑区水肿容积、CMT及眼压均低于对照组,差异均有统计学意义(P均<0.05)。干预后,两组炎症因子水平均降低,且观察组白细胞介素-6、细胞间黏附分子-1、血管内皮生长因子水平均低于对照组,差异均有统计学意义(P均<0.05)。两组并发症发生率比较,差异无统计学意义(P>0.05)。结论糖尿病黄斑水肿患者在眼底激光治疗的基础上联合雷珠单抗,能提高患者最佳矫正视力,降低黄斑区水肿容积、CMT及眼压水平,可减轻机体内炎症反应,且未增加并发症发生率。Objective To investigate the therapeutic effect and the influence on visual acuity of patients with diabetic macular edema based on fundus laser treatment combined with ranibizumab.Methods A total of 94 patients with dia-betic macular edema admitted to Shouguang People's Hospital from May 2023 to February 2024 were selected and di-vided into two groups according to different treatment methods,47 cases in each group.The control group was given fundus laser intervention,and the observation group was treated with ranibizumab on the basis of the control group.The best corrected visual acuity,macular edema volume,central macular thickness(CMT),intraocular pressure,in-flammatory factor levels and complication rate were compared between the two groups.Results After intervention,the best corrected visual acuity was improved and the macular edema volume,CMT and intraocular pressure levels were decreased in both groups,and the best corrected visual acuity in observation group was higher than that in control group,while the macular edema volume,CMT and intraocular pressure levels were lower than that in control group,and the differences were statistically significant(all P<0.05).After intervention,the levels of inflammatory factors in the two groups were reduced,and interleukin-6,intercellular adhesion molecule-1 and vascular endothelial growth factor in the observation group were lower than those in the control group,and the differences were statistically signifi-cant(all P<0.05).There was no significant difference in the incidence of complications between the two groups(P>0.05).Conclusion In patients with diabetic macular edema,combined with ranibizumab on the basis of fundus laser treatment can improve the best corrected visual acuity of patients,reduce the volume of macular edema,CMT and in-traocular pressure levels,alleviate the inflammation in the body,and do not increase the incidence of complications.

关 键 词：雷珠单抗 眼底激光 糖尿病黄斑水肿 视力水平 

分 类 号：R774[医药卫生—眼科]