枯草杆菌二联活菌联合双环醇治疗非酒精性脂肪肝致肝损伤的临床观察  

Clinical observation of live combined Bacillus subtilis and Enterococcus faecium combined with bicyclol in treating liver injury caused by non-alcoholic fatty liver disease

作　　者：姬霞 JI Xia(Jining First People's Hospital Sishui Branch Hospital,Jining 273200,China)

机构地区：[1]济宁市第一人民医院泗水院区,273200

出　　处：《中国现代药物应用》2025年第3期11-15,共5页Chinese Journal of Modern Drug Application

摘　　要：目的观察枯草杆菌二联活菌联合双环醇治疗非酒精性脂肪肝(NAFLD)致肝损伤对肝功能指标、血脂代谢、炎症因子水平的影响,分析治疗安全性。方法72例NAFLD致肝损伤患者,随机分为对照组和观察组,每组36例。对照组患者接受双环醇片治疗,观察组在对照组基础上加用枯草杆菌二联活菌肠溶胶囊治疗。比较两组患者的肝酶指标[谷丙转氨酶(ALT)、谷草转氨酶(AST)、γ-谷氨酰转肽酶(GGT)]、血脂指标[甘油三酯(TG)、总胆固醇(TC)]、体质量指数(BMI)、免疫指标[辅助性T细胞17(Th17)比例、调节性T细胞(Treg)比例、Th17/Treg]、肝脏超声检测结果,分析两组患者的用药安全性。结果治疗后,对照组患者的ALT、AST、GGT水平分别为(76.32±25.14)、(44.79±13.79)、(81.29±37.96)U/L,观察组患者分别为(53.33±33.79)、(29.32±14.64)、(65.94±30.71)U/L,治疗后,两组患者的ALT、AST、GGT水平均较本组治疗前出现了不同程度的下降,且观察组患者的下降程度明显大于对照组(P<0.05)。对照组患者的TG、TC、BMI分别为(1.61±0.39)mmol/L、(3.40±0.42)mmol/L、(25.33±2.69)kg/m^(2),观察组患者分别为(1.30±0.14)mmol/L、(2.69±0.45)mmol/L、(23.22±2.31)kg/m^(2)。治疗后,两组患者的TG、TC、BMI均较本组治疗前出现了不同程度的下降,且观察组患者的下降程度明显大于对照组(P<0.05)。治疗后,对照组患者的Th17比例、Treg比例、Th17/Treg分别为(9.86±2.46)%、(6.13±1.45)%、(1.33±0.15),观察组患者分别为(7.81±1.30)%、(7.22±1.53)%、(1.24±0.15)。治疗后,两组患者的Th17比例、Treg比例、Th17/Treg均较本组治疗前出现了不同程度的改善,且观察组患者的改善程度明显优于对照组(P<0.05)。治疗后,两组患者的脂肪肝严重程度较本组治疗前出现了不同程度的改善,且观察组患者的改善程度明显优于对照组(P<0.05)。在整个研究期间,两组患者均未出现明显的实验室指标异常,也未报告�Objective To observe the effect of live combined Bacillus subtilis and Enterococcus faecium combined with bicyclol on liver function indexes,lipid metabolism,and levels of inflammatory factors of patients with liver injury caused by non-alcoholic fatty liver disease(NAFLD),and analyze the safety of treatment.Methods 72 patients with liver injury caused by NAFLD were randomly divided into a control group and an observation group,with 36 cases in each group.The control group received treatment with bicyclol tablets,while the observation group,based on the control group,was additionally treated with live combined Bacillus subtilis and Enterococcus faecium.Patients in both groups were compared in terms of liver enzyme indicators[alanine aminotrasferase(ALT),aspartate transaminase(AST),gamma glutamyl transpeptidase(GGT)],blood lipid indicators[triglycerides(TG),total cholesterol(TC)],body mass index(BMI),immune indexes[T helper 17 cells(TH17)ratio,regulatory T cell(Treg)ratio,Th17/Treg],and liver ultrasound results.The medication safety of two groups was analyzed.Results After treatment,the levels of ALT,AST and GGT in the control group were(76.32±25.14),(44.79±13.79)and(81.29±37.96)U/L,while those in the observation group were(53.33±33.79),(29.32±14.64)and(65.94±30.71)U/L.After treatment,the levels of ALT,AST and GGT in both groups showed different degrees of decline compared with before treatment in this group,and the degree of decline in the observation group was significantly greater than that in the control group(P<0.05).TG,TC and BMI in the control group were(1.61±0.39)mmol/L,(3.40±0.42)mmol/L and(25.33±2.69)kg/m^(2),while those in the observation group were(1.30±0.14)mmol/L,(2.69±0.45)mmol/L and(23.22±2.31)kg/m^(2).After treatment,TG,TC and BMI in both groups showed different degrees of decline compared with before treatment in this group,and the degree of decline in the observation group was significantly greater than that in the control group(P<0.05).After treatment,Th17 ratio,Treg ratio and Th17/

关 键 词：非酒精性脂肪肝 枯草杆菌二联活菌 双环醇 肝损伤 

分 类 号：R575.5[医药卫生—消化系统]