内镜下黏膜切除术、内镜下黏膜剥离术在上消化道早期癌和癌前病变治疗中的应用价值  

Application value of endoscopic mucosal resection and endoscopic submucosal dissection in the treatment of early upper gastrointestinal cancer and precancerous lesions

作　　者：张艳芳 ZHANG Yan-fang(Geriatric Medicine Department,The Second Hospital of Jingzhou,Jingzhou 434000,China)

机构地区：[1]荆州市第二人民医院老年医学科,434000

出　　处：《中国现代药物应用》2025年第3期37-40,共4页Chinese Journal of Modern Drug Application

摘　　要：目的探究上消化道早期癌和癌前病变的治疗中应用内镜下黏膜切除术与内镜下黏膜剥离术的效果。方法100例上消化道早期癌和癌前病变患者,依据住院尾号单双数分组,单数为参照组(n=50,予以内镜下黏膜切除术),双数为实验组(n=50,予以内镜下黏膜剥离术)。对比两组治疗效果(整块切除率、治愈性切除率)及手术后疼痛程度、生活质量评分。结果实验组整块切除率、治愈性切除率分别为92.00%、84.00%,与参照组的70.00%、66.00%相比较高(P<0.05)。手术后,实验组无疼痛16例、轻度疼痛26例、中度疼痛5例、重度疼痛3例,参照组无疼痛8例、轻度疼痛25例、中度疼痛9例、重度疼痛8例。手术后,实验组疼痛程度与参照组相比较低(P<0.05)。实验组手术后认知功能、躯体功能、情绪功能、社会功能评分分别为(93.63±13.57)、(95.52±12.81)、(94.51±12.27)、(94.29±12.16)分,与参照组的(82.12±10.25)、(83.37±10.28)、(82.19±10.14)、(82.68±10.21)分相比较高(P<0.05)。结论在上消化道早期癌和癌前病变治疗中应用内镜下黏膜剥离术的效果较显著,可明显缓解其疼痛程度,改善患者预后生活质量,具有较强的可靠性,值得应用。Objective To explore the effect of endoscopic mucosal resection and endoscopic submucosal dissection in the treatment of early upper gastrointestinal cancer and precancerous lesions.Methods 100 patients with early upper gastrointestinal cancer and precancerous lesions were selected.According to the admission number,patients were assigned to reference group(n=50,odd number,endoscopic mucosal resection)and trial group(n=50,even number,endoscopic submucosal dissection).The treatment effect(total resection rate,curative resection rate),pain severity and quality of life score after the operation were compared between the two groups.Results The total resection rate and curative resection rate of the trial group were 92.00% and 84.00%,which were higher than 70.00% and 66.00% of the reference group(P<0.05).After the operation,the trial group had no pain in 16 cases,mild pain in 26 cases,moderate pain in 5 cases,severe pain in 3 cases;the reference group had no pain in 8 cases,mild pain in 25 cases,moderate pain in 9 cases,severe pain in 8 cases.After the operation,the pain severity of the trial group was lower than that of the reference group(P<0.05).After the operation,the scores of cognitive function,physical function,emotional function and social function in the trail group were(93.63±13.57),(95.52±12.81),(94.51±12.27)and(94.29±12.16)points,which were higher than(82.12±10.25),(83.37±10.28),(82.19±10.14)and(82.68±10.21)points in the control group(P<0.05).Conclusion The application of endoscopic submucosal dissection has a significant effect in the treatment of early upper gastrointestinal cancer and precancerous lesions,and can significantly relieve the pain severity,improve the prognosis and quality of life of patients.It has strong reliability,and is worthy of application.

关 键 词：内镜下黏膜剥离术 内镜下黏膜切除术 上消化道早期癌 癌前病变 应用价值 

分 类 号：R735[医药卫生—肿瘤]