结直肠癌根治术后短期内复发的危险因素分析  

Analysis of risk factors for short-term recurrence after radical surgery for colorectal cancer

作　　者：李小辉 LI Xiaohui(Department One of Surgery,Ganxi Cancer Hospital,Pingxiang 337000,China)

机构地区：[1]萍乡赣西肿瘤医院外一科,337000

出　　处：《中国现代药物应用》2025年第3期41-43,共3页Chinese Journal of Modern Drug Application

摘　　要：目的探讨结直肠癌根治术后短期内复发的危险因素。方法回顾性分析100例结直肠癌根治术患者的临床病历资料,回访期为术后1年内,其中复发患者42例,未复发患者58例。采用单因素分析结直肠癌根治术后1年内复发患者与未复发患者的年龄、性别、肿瘤大小、肿瘤原发部位、T分期、根治性手术方式、新辅助化疗疗效,以Logistic多因素回归分析结直肠癌根治术后1年内复发的危险因素。结果结直肠癌根治术后1年内复发患者中肿瘤原发部位为右半结肠的占比59.52%(25/42)高于未复发患者的31.03%(18/58),T_(3~4)期占比73.81%(31/42)高于未复发患者的39.66%(23/58),新辅助化疗疗效无效或未做占比64.29%(27/42)高于未复发患者的34.48%(20/58),差异具有统计学意义(P<0.05)。复发患者与未复发患者的年龄、性别、肿瘤大小、根治性手术方式比较,差异无统计学意义(P>0.05)。Logistic多因素回归分析显示,肿瘤原发部位为右半结肠、T分期为T_(3~4)期以及新辅助化疗疗效无效或未做是结直肠癌根治术后1年内复发的独立危险因素(P<0.05)。结论肿瘤原发部位为右半结肠、T分期为T_(3~4)期以及新辅助化疗疗效无效或未放是结直肠癌根治术后短期内复发的独立危险因素,其中肿瘤原发部位为右半结肠的患者复发率高于左半结肠的患者。Objective To explore the risk factors for short-term recurrence after radical surgery for colorectal cancer.Methods The clinical data of 100 patients with colorectal cancer who underwent radical resection were retrospectively analyzed.They were followed-up within 1 year after surgery,with 42 patients had recurrence and 58 patients had no recurrence.Univariate analysis was used to analyze the age,gender,tumor size,primary tumor site,T stage,radical surgical approach,and neoadjuvant chemotherapy efficacy in patients with and without recurrence within 1 year after radical resection for colorectal cancer;multivariate Logistic regression analysis was used to analyze the independent risk factors of recurrence within 1 year after radical resection for colorectal cancer.Results Within 1 year after radical surgery for colorectal cancer,59.52%(25/42)of patients with recurrence had a tumor primary site in the right colon,which was higher than 31.03%(18/58)of patients without recurrence;the percentage of T_(3-4) stages in patients with recurrence was 73.81%(31/42),which was higher than 39.66%(23/58)in patients without recurrence;64.29%(27/42)of patients with recurrence had no therapeutic effect or did not do neoadjuvant chemotherapy,which was higher than 34.48%(20/58)of patients without recurrence;the difference was statistically significant(P<0.05).There was no significant difference in age,gender,tumor size and radical surgical approach between patients with recurrence and those without recurrence(P>0.05).Multivariate Logistic regression analysis showed that primary tumor site in the right colon,T staging of T_(3-4) and inefficacy or absence of neoadjuvant chemotherapy were independent risk factors for recurrence within 1 year after radical surgery for colorectal cancer(P<0.05).Conclusion Primary tumor site in the right colon,T staging of T_(3-4) and inefficacy or absence of neoadjuvant chemotherapy are independent risk factors of recurrence within 1 year after radical resection for colorectal cancer.

关 键 词：结直肠癌 肿瘤根治术 复发 危险因素 

分 类 号：R735.34[医药卫生—肿瘤]