银杏达莫注射液联合注射用奥扎格雷钠治疗脑梗死的效果分析  

Effect analysis of ginkgo leaf extract and dipyridamole injection combined with ozagrel sodium for injection on cerebral infarction

作　　者：李业永 LI Ye-yong(Department of Pharmacy,Tai'an Hospital of Traditional Chinese Medicine,Tai'an 271000,China)

机构地区：[1]泰安市中医医院药学部,271000

出　　处：《中国现代药物应用》2025年第3期70-73,共4页Chinese Journal of Modern Drug Application

摘　　要：目的探讨银杏达莫注射液联合注射用奥扎格雷钠治疗脑梗死的效果。方法96例脑梗死患者,根据随机数字表法分为对照组和观察组,每组48例。对照组单纯给予注射用奥扎格雷钠治疗,观察组在对照组基础上给予银杏达莫注射液治疗。对比两组临床疗效、并发症发生情况、血流动力学指标、美国国立卫生研究院卒中量表(NIHSS)评分。结果观察组治疗总有效率95.83%高于对照组的81.25%(P<0.05)。两组并发症发生率对比无明显差异(P>0.05)。治疗后,观察组血浆粘度(1.52±0.33)mPa·s、全血粘度(4.12±0.82)mPa·s、纤维蛋白原(3.18±1.42)g/L、血小板粘附率(30.15±1.42)%、血浆一氧化氮(15.24±2.55)μmol/L、内皮素(50.33±3.82)ng/L水平均明显低于对照组的(1.75±0.36)mPa·s、(5.66±0.42)mPa·s、(3.99±0.80)g/L、(33.28±1.28)%、(26.06±2.92)μmol/L、(67.42±3.20)ng/L(P<0.05)。治疗后,观察组患者NIHSS评分(11.20±0.58)分明显低于对照组的(16.24±0.70)分(P<0.05)。结论对脑梗死患者而言,银杏达莫注射液联合注射用奥扎格雷钠治疗的临床疗效显著,值得临床采纳并推广。Objective To explore the effect of ginkgo leaf extract and dipyridamole injection combined with ozagrel sodium for injection on cerebral infarction.Methods 96 patients with cerebral infarction were divided into control group and observation group according to random number table method,with 48 cases in each group.The control group was treated with ozagrel sodium for injection alone,and the observation group was treated with ginkgo leaf extract and dipyridamole injection on the basis of the control group.The clinical efficacy,complications,hemodynamic indexes and the score of National Institutes of Health Stroke Scale(NIHSS)were compared between the two groups.Results The total effective rate of 95.83% in the observation group was higher than 81.25% in the control group(P<0.05).There was no significant difference in complication rate between the two groups(P>0.05).After treatment,the observation group had plasma viscosity of(1.52±0.33)mPa·s,whole blood viscosity of(4.12±0.82)mPa·s,fibrinogen of(3.18±1.42)g/L,platelet adhesion rate of(30.15±1.42)%,plasma nitric oxide of(15.24±2.55)μmol/L and endothelin of(50.33±3.82)ng/L,which were significantly lower than(1.75±0.36)mPa·s,(5.66±0.42)mPa·s,(3.99±0.80)g/L,(33.28±1.28)%,(26.06±2.92)μmol/L and(67.42±3.20)ng/L in the control group(P<0.05).After treatment,the observation group had significantly lower NIHSS score of(11.20±0.58)points than(16.24±0.70)points in the control group(P<0.05).Conclusion The combination of ginkgo leaf extract and dipyridamole injection and ozagrel sodium for injection has significant clinical efficacy in treating patients with cerebral infarction,and is worthy of clinical adoption and promotion.

关 键 词：脑梗死 银杏达莫注射液 注射用奥扎格雷钠 并发症 临床疗效 

分 类 号：R743.33[医药卫生—神经病学与精神病学]