基础治疗联合盐酸米诺环素治疗牙周病的疗效及安全性探讨  

Efficacy and safety of basic therapy combined with minocycline hydrochloride in the treatment of periodontal disease

作　　者：申璐 谢花花 SHEN Lu;XIE Hua-hua(Quannan County Center for Disease Control and Prevention,Ganzhou 341800,China)

机构地区：[1]全南县疾病预防控制中心,341800 [2]全南县人民医院口腔科,341800

出　　处：《中国现代药物应用》2025年第3期124-127,共4页Chinese Journal of Modern Drug Application

摘　　要：目的探讨基础治疗联合盐酸米诺环素治疗牙周病的疗效及安全性。方法88例牙周病患者,随机分为对照组和实验组,每组44例。对照组予以基础治疗,实验组则在基础治疗的同时联合使用盐酸米诺环素。对比两组临床疗效、康复指标[牙龈指数(GI)、菌斑指数(PLI)、探诊深度(PD)、龈沟出血指数(SBI)]、龈沟液炎性因子[白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、前列腺素E_(2)(PGE_(2))]水平以及不良事件发生情况。结果实验组的治疗总有效率97.73%高于对照组的84.09%(P<0.05)。实验组治疗后GI(0.86±0.17)分、PLI(1.25±0.18)分、PD(2.67±0.47)mm、SBI(1.57±0.31)分均明显优于对照组的(1.51±0.25)分、(1.87±0.24)分、(3.39±0.51)mm、(2.13±0.38)分(P<0.05)。实验组治疗后龈沟液中IL-1β(3.74±0.81)ng/L、PGE_(2)(5.03±1.02)ng/ml、IL-6(48.54±5.25)ng/L均较对照组的(5.75±1.07)ng/L、(7.78±1.57)ng/ml、(56.45±6.36)ng/L显著降低(P<0.05)。两组不良事件发生率对比无明显差异(P>0.05)。结论在牙周病治疗中联合应用基础治疗与盐酸米诺环素疗效显著,能促使GI、PLI、PD、SBI及龈沟液中炎性因子水平得到改善,且不会增加不良事件,该治疗方案值得在牙周病治疗中推广应用。Objective To explore the efficacy and safety of basic therapy combined with minocycline hydrochloride in the treatment of periodontal disease.Methods 88 patients with periodontal disease were randomly divided into control group and experimental group,with 44 cases in each group.The control group was given basic therapy,and the experimental group was given minocycline hydrochloride in combination with basic therapy.Both groups were compared in terms of clinical efficacy,rehabilitation indexes[gingival index(GI),plaque index(PLI),probing depth(PD),sulcus bleeding index(SBI)],inflammatory factors[interleukin-1β(IL-1β),interleukin-6(IL-6),prostaglanin E_(2)(PGE_(2))]in gingival crevicular fluid and the occurrence of adverse events.Results The total effective rate of 97.73%in the experimental group was higher than 84.09%in the control group(P<0.05).After treatment,the experimental group had GI of(0.86±0.17)points,PLI of(1.25±0.18)points,PD of(2.67±0.47)mm and SBI of(1.57±0.31)points,which were significantly better than(1.51±0.25)points,(1.87±0.24)points,(3.39±0.51)mm and(2.13±0.38)points in the control group(P<0.05).After treatment,the experimental group had IL-1βof(3.74±0.81)ng/L,PGE_(2) of(5.03±1.02)ng/ml and IL-6 of(48.54±5.25)ng/L,which were significantly lower than(5.75±1.07)ng/L,(7.78±1.57)ng/ml and(56.45±6.36)ng/L in the control group(P<0.05).There was no significant difference in the incidence of adverse events between the two groups(P>0.05).Conclusion The combination of basic therapy and minocycline hydrochloride is effective in the treatment of periodontal disease,and can improve the levels of inflammatory factors of GI,PLI,PD,SBI in gingival crevicular fluid without increasing adverse events.This treatment regimen is worthy of promotion and in the treatment of periodontal disease.

关 键 词：牙周病 盐酸米诺环素 基础治疗 炎性因子 不良事件 

分 类 号：R781.4[医药卫生—口腔医学]