直肠癌新辅助治疗后局部再生研究进展  

Progress in research of local regrowth after neoadjuvant therapy in rectal cancer

作　　者：袁兴梅 曹钦兴 严力 侯能易[3] 余松 陆河江 张敏[5] 庞明辉 Xing-Mei Yuan;Qin-Xing Cao;Li Yan;Neng-Yi Hou;Song Yu;He-Jiang Lu;Min Zhang;Ming-Hui Pang(School of Medicine,University of Electronic Science and Technology,Chengdu 610054,Sichuan Province,China;Department of Geriatric Surgery,The First People’s Hospital of Yibin,Yibin 644000,Sichuan Province,China;Department of Geriatric Surgery,Sichuan Academy of Medical Sciences&Sichuan Province People’s Hospital(Affiliated Hospital of University of Electronic Science and Technology),Chengdu 610072,Sichuan Province,China;School of Clinical Medicine,Southwest Medical University,Luzhou 646000,Sichuan Province,China;Department of Outpatient,Sichuan Academy of Medical Sciences&Sichuan Province People’s Hospital(Affiliated Hospital of University of Electronic Science and Technology),Chengdu 610072,Sichuan Province,China)

机构地区：[1]电子科技大学医学院,四川省成都市610054 [2]宜宾市第一人民医院胃肠外科,四川省宜宾市644000 [3]四川省医学科学院·四川省人民医院(电子科技大学附属医院)老年普通外科,四川省成都市610072 [4]西南医科大学临床医学院,四川省泸州市646000 [5]四川省医学科学院·四川省人民医院(电子科技大学附属医院)门诊部,610072

出　　处：《世界华人消化杂志》2025年第1期37-44,共8页World Chinese Journal of Digestology

基　　金：成都市重点研发项目,No.2024-YF05-0714-SN;四川省干部保健科研项目,No.川干研2023-209和No.川干研2023-205;电子科技大学-四川省人民医院“医工交叉联合基金”,No.ZYGX2021YGLH212.

摘　　要：新辅助治疗后直肠癌的局部再生问题在临床上备受关注.直肠癌患者接受术前放化疗之后,局部肿瘤残留或再生成为重要的临床挑战.针对局部肿瘤残留或再生的发生机制、潜在风险因素以及处理策略的研究逐渐展开.现有研究表明,新辅助治疗能降低直肠癌局部再生的发生率,但局部再生的预防和处理仍然是亟待解决的临床问题.未来研究需要进一步明确肿瘤微环境在局部再生中的作用,深入探究直肠癌局部再生的潜在机制,并制定更加精准和个体化的治疗方案.此外,对微小残留病灶研究的深入及影像组学技术的发展等也为“观察等待”策略的管理提供了新的视角与可能性.本文主要围绕直肠癌患者新辅助治疗后局部再生的研究现状进行总结和未来的研究方向进行展望.The issue of local regrowth after neoadjuvant therapy in rectal cancer patients has attracted significant clinical attention.Following preoperative chemoradiotherapy,the persistence or regrowth of local tumors presents a critical clinical challenge.Research into the mechanisms,potential risk factors,and management strategies for local tumor persistence or regrowth is underway.Existing studies suggest that neoadjuvant therapy can reduce the occurrence of local regrowth in rectal cancer,but prevention and management of local regrowth remain urgent clinical issues.Future research needs to further clarify the role of the tumor microenvironment in local regrowth,delve into the potential mechanisms of rectal cancer local regrowth,and develop more precise and personalized treatment strategies.In addition,in-depth research on minimal residual disease and development of imaging genomics technology provide new perspectives and possibilities for the management of“watch and wait”strategies.This article provides a summary of the current research on local regrowth in rectal cancer patients after neoadjuvant therapy and prospects for future research directions.

关 键 词：直肠癌 新辅助治疗 局部再生 微小残留病灶 

分 类 号：R73[医药卫生—肿瘤]