不同亚型FD患者血浆Ghrelin、NPY和UCN-1的水平研究  

Plasma levels of ghrelin,neuropeptide Y,and urocortin-1 in patients with different subtypes of functional dyspepsia

作　　者：朱亚娜 任雅迪 李路 牛燕青 王绕绕 李熳[1] Ya-Na Zhu;Ya-Di Ren;Lu Li;Yan-Qing Niu;Rao-Rao Wang;Man Li(Department of Gastroenterology,The Second Hospital of Tianjin Medical University,Tianjin 300202,China;Department of Gastroenterology,Handan Central Hospital,Handan 056000,Hebei Province,China)

机构地区：[1]天津医科大学第二医院消化内科,天津市300202 [2]邯郸市中心医院消化内科,河北省邯郸市056000

出　　处：《世界华人消化杂志》2025年第1期62-69,共8页World Chinese Journal of Digestology

基　　金：天津市卫生健康科技项目,No.TJWJ2021MS017.

摘　　要：背景功能性消化不良(functional dyspepsia,FD)是一种普遍存在的消化系统疾病,其所占用的医疗资源也在逐年增加.脑肠轴功能紊乱被认为是其重要的发病机制,脑肠肽在肠脑轴中具有重要的调节作用.本研究检测血浆酰基化胃饥饿素(acyl ghrelin,AG)、去酰基化胃饥饿素(des-acyl ghrelin,DAG)、神经肽Y(neuropeptide Y,NPY)和尿皮质素-1(urocortin-1,UCN1)水平,并进行广泛性焦虑障碍量表及病人健康问卷抑郁量表问卷,揭示FD相关.目的分析不同亚型FD患者血浆AG、DAG、NPY和UCN1的水平差异及FD患者的精神心理状况特点,为临床治疗提供有效的理论支持.方法选取2022-02/2023-03就诊于天津医科大学第二医院消化内科病房的FD患者53例(均符合RomeⅣ诊断标准),其中餐后不适综合征(postprandial discomfort syndrome,PDS)组19例、重叠综合征组19例及上腹痛综合征(epigastrium pain syndrome,EPS)组15例.对照组为同一时间段15例健康体检者.所有研究对象均采用酶联免疫分析法检测血浆AG、DAG、NPY和UCN-1水平,并进行广泛性焦虑障碍量表及病人健康问卷抑郁量表问卷.结果(1)PDS组血浆AG水平较健康对照组降低(P<0.001),并且较EPS组(P<0.001)及重叠综合征组(P=0.030)也明显降低;重叠综合征组血浆AG水平较健康对照组(P=0.017)及EPS组(P=0.008)均显著降低;而EPS组与健康对照组比较,差异无统计学意义(P=0.684);(2)血浆DAG水平在PDS组与健康对照组之间(P=0.458)、EPS组与健康对照组之间(P=0.638)、重叠综合征组与健康对照组之间(P=0.612)、PDS组与EPS组之间(P=0.170)、PDS组与重叠综合征组之间(P=0.709)及EPS组与重叠综合征组之间(P=0.239)差异均无统计学意义;(3)PDS组血浆NPY水平较健康对照组降低(P=0.043),且较EPS组(P=0.044)及重叠综合征组(P=0.049)也降低;而在EPS组血浆NPY水平与健康对照组比较(P=0.971)、EPS组与重叠综合征组比较(P=0.929)及重叠综合征组与健康对照�BACKGROUND Functional dyspepsia(FD)is a common disease of the digestive system,and its burden on medical resources is increasing year by year.Brain-gut axis dysfunction is considered to be an important pathogenesis of the disease,and brain-gut peptide plays an important role in the regulation of the brain-gut axis.In this study,plasma levels of acyl ghrelin(AG),desacyl ghrelin(DAG),neuropeptide Y(NPY),and urocortin-1(UCN-1)were measured,and generalized Anxiety Disorder Scale and Patient Health Questionnaire Depression Scale were used to assess the psychosocial status of patients to reveal their differences among different FD subtypes.AIM To determine the plasma levels of AG,DAG,NPY and UCN-1 in patients with different subtypes of FD,and to investigate the psychosocial status of patients with FD,in order to find effective theoretical support for clinical treatment.METHODS From February 2022 to March 2023,53 patients with FD(all meeting Rome IV diagnostic criteria)were selected from the Department of Gastroenterology of the Second Hospital of Tianjin Medical University,including 19 cases in postprandial discomfort syndrome(PDS)group,19 cases in overlap syndrome group,and 15 cases in epigastric pain syndrome(EPS)group.Fifteen healthy volunteers who underwent medical check-ups during the same time period were selected as a healthy control group.All study subjects were tested for plasma AG,DAG,NPY,and UCN-1 levels by enzyme-linked immunoassay,and four scales,namely,the Nepean Dyspepsia Symptom Index Rating Scale,Nepean Quality of Life Index Rating Scale,Generalized Anxiety Disorder Scale,and Patient Health Questionnaire Depression Scale,were used to assess the psychosocial status of the subjects.RESULTS The level of serum AG in the PDS group was lower than those of the control(P<0.001),EPS(P<0.001),and overlap syndrome groups(P=0.030).The level of serum AG in the overlap syndrome group was lower than those of the control(P=0.017)and EPS groups(P=0.008).However,no significant difference was found in serum AG between th

关 键 词：功能性消化不良 餐后不适综合征 上腹痛综合征 胃饥饿素 神经肽Y 尿皮质素-1 焦虑 抑郁 

分 类 号：R47[医药卫生—护理学]