膜突蛋白在肿瘤发展及诊治中的研究进展  

Research progress of moesin in tumor development,diagnosis and treatment

作　　者：孙媛媛 张钟予 张燕燕[1] 杨家梅[1] SUN Yuanyuan;ZHANG Zhongyu;ZHANG Yanyan;YANG Jiamei(Department of Oncology,the Second Affiliated Hospital of Zhengzhou University,Henan Zhengzhou 450000,China)

机构地区：[1]郑州大学第二附属医院肿瘤科,河南郑州450000

出　　处：《现代肿瘤医学》2025年第3期473-478,共6页Journal of Modern Oncology

基　　金：国家自然科学基金资助项目(编号:82170183)。

摘　　要：膜突蛋白是埃兹蛋白-根蛋白-膜突蛋白(Ezrin-Radixin-Moesin,ERM)家族成员,连接着细胞膜与细胞骨架,参与维持细胞的形态及完整性、形成细胞表面特化结构,并通过调节细胞信号转导调控细胞黏附、生长、迁移。膜突蛋白不仅参与血管内皮细胞调控,还调控细胞骨架和细胞信号转导,来影响免疫系统疾病的发展过程,同时膜突蛋白与乳腺癌、肝癌、胃癌、结直肠癌、神经胶质瘤等多种肿瘤的发生、发展及预后密切相关,有望成为潜在的肿瘤分子标记物,与肿瘤预后有关。该文就膜突蛋白在各个肿瘤系统中的研究进展作一综述。As a member of the Ezrin-Radixin-Moesin(ERM) family,moesin is a link protein between cell membrane and cytoskeleton,which is involved in the maintenance of cell morphology and integrity and the formation of specialized cell surface structures.It also regulates cell adhesion,growth,and migration by regulating cell signal transduction.Moesin not only plays a key role in the regulation of vascular endothelial cells,but also participates in the occurrence and development of immune system diseases through cytoskeleton and cell signal transduction.At the same time,studies have found that moesin is closely related to the occurrence,development and prognosis of breast cancer,liver cancer,gastric cancer,colorectal cancer,glioma and other tumors.And moesin is expected to become a potential tumor molecular marker which is related to tumor prognosis.This article reviews the research progress of moesin in various tumors.

关 键 词：膜突蛋白 肿瘤 治疗 研究进展 

分 类 号：R730.231[医药卫生—肿瘤]