桥粒胶蛋白2在消化系统和其他系统肿瘤中作用的研究进展  

Research progress on the role of DSC-2 in tumors of digestive system and other systemic cancers

作　　者：闫沛慈 郭然 李刚[3] 胡蕊[2] 王向南 胡晓 YAN Peici;GUO Ran;LI Gang;HU Rui;WANG Xiangnan;HU Xiao(Department of Pathophysiology,Hebei Medical University,Hebei Shijiazhuang 050017,China;The Second Affiliated Hospital of Hebei Medical University,Hebei Shijiazhuang 050061,China;Hebei Provincial People's Hospital,Hebei Shijiazhuang 050051,China)

机构地区：[1]河北医科大学病理生理学教研室,河北石家庄050017 [2]河北医科大学附属第二医院,河北石家庄050061 [3]河北省人民医院,河北石家庄050051

出　　处：《现代肿瘤医学》2025年第3期487-493,共7页Journal of Modern Oncology

基　　金：国家自然科学基金项目(编号:82103457);河北省自然科学基金(编号:H2023307028);河北省高等学校科学技术研究项目(编号:BJK2023025);河北省卫生健康委医学科学研究课题计划项目(编号:20240370)。

摘　　要：桥粒胶蛋白2(desmocollin-2,DSC-2)是桥粒蛋白的重要组成部分,它在细胞膜表面上起到连接细胞的作用,是细胞黏附的一个关键因子。DSC-2的表达失调与诸多疾病的病理过程紧密相关,其中包括肿瘤性疾病。已有研究证实DSC-2的异常表达与肿瘤的发生发展密切相关,并且常常提示肿瘤的转移和侵袭能力增强。该文综述了DSC-2的生理功能及其异常表达在消化系统和其他肿瘤中发挥的作用及机制,旨在阐明DSC-2的异常表达与肿瘤性疾病的致病机制和临床关联,为开发和应用桥粒蛋白家族相关的肿瘤评价指标和临床治疗靶点提供必要的理论依据。Desmocollin-2(DSC-2) is an important component of desmosomal proteins,playing a role in cell-to-cell adhesion at the cell membrane surface and serving as a key factor in cell adhesion.The dysregulation of DSC-2 expression is closely related to the pathological processes of many diseases,including oncological disorders.Studies have confirmed that the abnormal expression of DSC-2 is closely associated with the initiation and progression of cancer and often indicates an enhancement of tumor metastasis and invasiveness.This review summarizes the physiological functions of DSC-2 and the impact of its abnormal expression in different tumors of digestive system and other systems.The aim of this article is to elucidate the pathogenic mechanisms and clinical correlations of abnormal DSC-2 expression in oncological diseases,providing the necessary theoretical basis for the development and application of desmosomal protein family-related tumor evaluation indicators and clinical therapeutic targets.

关 键 词：DSC-2 肿瘤 信号通路 转移侵袭 治疗靶点 

分 类 号：R730.5[医药卫生—肿瘤]