中药内服联合艾灸治疗溃疡性结肠炎的疗效和安全性的系统评价和荟萃分析  

Efficacy and Safety of Oral Administration of Traditional Chinese Medicine Combined with Moxibustion in the Treatment of Ulcerative Colitis:A Systematic Review and Meta-analysis

作　　者：王祎庭 陈龑 郭修田[1] 张少军[2] Wang Yiting;Chen Yan;Guo Xiutian;Zhang Shaojun(Shanghai University of Traditional Chinese Medicine Affiliated Shanghai Municipal Hospital of Traditional Chinese Medicine,Shanghai 200071,China)

机构地区：[1]上海中医药大学附属市中医医院,上海200071 [2]上海市嘉定区中医医院,上海201800

出　　处：《中国中医急症》2025年第2期189-193,199,共6页Journal of Emergency in Traditional Chinese Medicine

基　　金：国家自然科学基金青年项目(82405390);上海市科委项目“科技创新行动计划”(23Y11920800)。

摘　　要：目的评价中药联合艾灸治疗溃疡性结肠炎的有效性及安全性。方法利用中国知网(CNKI)、中文科技期刊数据库(VIP)及PubMed数据库,根据关键词和主题词检索后对文献进行筛选,并对符合标准的文献进行质量评估,将临床总有效率、肠镜下黏膜评分、肿瘤坏死因子-α(TNF-α)水平、不良反应发生率作为结局指标,运用RevMan5.4软件进行Meta分析。结果共检索出116篇文献,参照标准筛选后共纳入16篇随机对照试验(RCT)文献,共1388位患者。治疗组临床有效率[RR=1.25,95%CI(1.18~1.32),P<0.00001]高于对照组,治疗组的肠镜下黏膜评分[MD=-0.73,95%CI(-1.06~-0.40),P<0.00001]优于对照组,同时治疗组在减少炎症介质、不良反应发生率方面均优于对照组,差异有统计学意义(P<0.00001)。结论中药联合艾灸的疗法优于单纯使用西药,中医药在治疗UC方面具有一定疗效。Objective:To evaluate the effectiveness and safety of traditional Chinese medicine(TCM)combined with moxibustion in the treatment of ulcerative colitis(UC).Methods:Data were retrieved from three databases:China National Knowledge Infrastructure(CNKI),VIP database and PubMed.A systematic search through medical databases by using appropriate keywords was conducted.Papers were screened according to the inclusion and ex⁃clusion criteria,then the quality of screened literature was evaluated.The primary outcomes were the total effective rate,colonoscopy mucosal score,the level of TNF-αand prevalence of adverse reactions.Meta-analysis of the col⁃lected data was performed using RevMan5.4.Results:A total of 116 papers were initially identified.Upon apply⁃ing the inclusion and exclusion criteria,100 papers were excluded,resulting in the inclusion of 16 studies encom⁃passing 1388 patients.The clinical effective rate of the treatment group[RR=1.25,95%CI(1.18~1.32),P<0.00001]was higher than that of the control group.The endoscopic mucosal score of the treatment group[MD=-0.73,95%CI(-1.06~-0.40),P<0.00001]was better than that of the control group.Moreover,the treatment group showed better results than the control group in reducing inflammatory mediators and the incidence of adverse reac⁃tions,and the differences were statistically significant(P<0.00001).Conclusion:The combined therapy of oral administration of TCM and moxibustion shows better results compared with the Western medicine alone,indicating that traditional Chinese medicine has a certain efficacy in the treatment of UC.

关 键 词：溃疡性结肠炎 中医药 艾灸 META分析 文献检索 

分 类 号：R574.62[医药卫生—消化系统]