钇-90选择性内放射治疗肝癌的过去、现在与未来  

Yttrium-90 selective internal radiation therapy on liver cancer:the past,the present,and the future

作　　者：马婧嶔 张林泓 杨敏捷 蔡加彬[4] 方颖 刘嵘 瞿旭东 刘凌晓 颜志平 MA Jingqin;ZHANG Linhong;YANG Minjie;CAI Jiabin;FANG Ying;LIU Rong;QU Xudong;LIU Lingxiao;YAN Zhiping(Department of Interventional Radiology,Zhongshan Hospital,Fudan University,Shanghai 200032,China;Shanghai Institution of Medical Imaging,Shanghai 200032,China;National Clinical Research Center for Interventional Medicine,Shanghai 200032,China;Department of Liver Surgery and Transplantation,Zhongshan Hospital,Fudan University,Shanghai 200032,China;Department of Gastroenterology,Zhongshan Hospital,Fudan University,Shanghai 200032,China)

机构地区：[1]复旦大学附属中山医院介入治疗科,上海200032 [2]上海市影像医学研究所,上海200032 [3]国家放射与治疗医学临床研究中心,上海200032 [4]复旦大学附属中山医院肝胆肿瘤和肝移植外科,上海200032 [5]复旦大学附属中山医院消化科,上海200032

出　　处：《中国临床医学》2025年第1期3-8,共6页Chinese Journal of Clinical Medicine

基　　金：国家自然科学基金(82302323),上海市科学技术委员会基金(22ZR1460800).

摘　　要：钇-90选择性内放射治疗(Yttrium-90 selective internal radiation therapy,90Y-SIRT)是一种通过将放射性微球精准输送至肿瘤动脉血管床,利用β射线对肿瘤组织进行局部高剂量放射治疗的技术。该技术已在不可手术的原发性肝癌及转移性肝癌患者中展现出显著疗效。本文系统综述了90Y-SIRT在肝癌治疗中的发展历程和临床应用现状,并展望其未来发展方向。Yttrium-90 selective internal radiation therapy(90Y-SIRT)is a treatment technique that delivers radioactive microspheres precisely to the arterial vascular bed of neoplasms,utilizing beta radiation to administer a high local dose of radiation to the neoplasm tissues.This technology has demonstrated significant efficacy in patients with unresectable pirmary liver cancers and liver metastases.This article systematically reviews the development history and clinical application status of 90Y-SIRT in the treatment of liver cancer,and looks forward to future development directions.

关 键 词：钇-90 选择性内放射治疗 肝癌 

分 类 号：R735.7[医药卫生—肿瘤]