钇-90树脂微球选择性内放射治疗肝右叶巨块型肝癌1例报告  

Yttrium-90 resin microsphere selective internal radiation therapy on giant hepatocellular carcinoma in right lobe of liver:a case report

作　　者：李诺亚 许明星[1] 徐见亮[1] LI Nuoya;XU Mingxing;XU Jianliang(Department of Liver Surgery,the Third Affiliated Hospital,Sun Yat-sen University,Guangzhou 510000,Guangdong,China)

机构地区：[1]中山大学附属第三医院肝胆外科,广州510000

出　　处：《中国临床医学》2025年第1期35-40,共6页Chinese Journal of Clinical Medicine

摘　　要：原发性肝癌是中国常见的恶性肿瘤,目前主要治疗手段包括手术切除、肝移植、介入治疗、射频消融、化疗、靶向治疗及免疫治疗等。钇-90微球选择性内放射治疗(Yttrium-90 microsphere selective internal radiation therapy,^(90)Y-SIRT)是不适合手术切除的中晚期肝癌的重要转化治疗手段。本文报告中山大学附属第三医院采用^(90)Y树脂微球治疗肝右叶巨块型肝癌患者1例,治疗后肿瘤显著坏死缩小,甲胎蛋白(alpha fetoprotein,AFP)水平显著下降,患者临床症状明显改善,体现^(90)Y-SIRT在控制肿瘤和改善患者生存质量方面的显著效果。Primary liver cancer is a common malignant tumor in China.The current main treatment methods include surgical resection,liver transplantation,interventional therapy,radiofrequency ablation,chemotherapy,targeted therapy,and immunotherapy.Yttrium-90 microsphere selective internal radiation therapy(^(90)Y-SIRT)represents a critical treatment option for converting unresectable intermediate to advanced hepatocellular carcinoma.This report details a case of a patient with a giant hepatocellular carcinoma in the right lobe treated with ^(90)Y resin microsphere at the Third Affiliated Hospital of Sun Yat-sen University.Post-treatment,the tumor showed significant necrosis and reduction in size,with a marked decrease in alpha fetoprotein(AFP)levels and notable improvement in clinical symptoms.The case highlights the substantial efficacy of ^(90)Y-SIRT in controlling tumor progression and enhancing patient quality of life.

关 键 词：钇-90树脂微球 选择性内放射治疗 巨块型肝癌 

分 类 号：R735.7[医药卫生—肿瘤]