丝氨酸羟甲基转移酶抑制剂在肿瘤治疗中的研究进展  

Research progress of serine hydroxymethyltransferase inhibitors in tumor treatment

作　　者：陈宜利 王培森 陈昱灵 曾园园[1] CHEN Yili;WANG Peisen;CHEN Yuling;ZENG Yuanyuan(Department of Pulmonary and Critical Care Medicine,The First Affiliated Hospital of Soochow University,Suzhou 215006,Jiangsu,China)

机构地区：[1]苏州大学附属第一医院呼吸与危重症医学科,苏州215006

出　　处：《中国临床医学》2025年第1期125-134,共10页Chinese Journal of Clinical Medicine

基　　金：国家自然科学基金(82272648);江苏省高等学校自然科学研究项目(22KJB320006).

摘　　要：肿瘤是细胞长期、无限增殖的结果。肿瘤细胞通过调整各种代谢通量,以满足增加的生物能量和生物合成需求。丝氨酸是人体8种非必需氨基酸之一,在多种生理活动中发挥重要作用,为细胞增殖提供一碳单位、甘氨酸等。丝氨酸羟甲基转移酶(serine hydroxymethyltransferase,SHMT)是催化丝氨酸和甘氨酸转化的关键酶,在多种肿瘤中高表达,是抗肿瘤药物的潜在靶点。本文综述了SHMT作为肿瘤治疗新靶点的潜力及其抑制剂在肿瘤临床前研究中的进展,为新型肿瘤靶向药物研发提供参考。Tumor is the result of long-term and unlimited proliferation of cells.Tumor cells adjust various metabolic fluxes to meet increased bioenergy and biosynthetic requirements.Serine is one of the eight non-essential amino acids in the human body.It plays an important role in a variety of physiological activities and can provide one carbon unit,glycine,etc.for cell proliferation.Serine hydroxymethyltransferase(SHMT)is a key enzyme that catalyzes the conversion of glycine and serine.It is highly expressed in a variety of tumors and is a potential target for anti-tumor drugs.This article focuses on the potential of SHMT as a new target for cancer treatment and the preliminary application of its inhibitors in preclinical studies of tumors,providing reference for the development of new targeted drugs for tumors.

关 键 词：肿瘤 丝氨酸代谢 丝氨酸羟甲基转移酶抑制剂 

分 类 号：R730.5[医药卫生—肿瘤]