基于生物信息学方法鉴定抑郁症与帕金森病共同关键基因  

Identification of common key genes of depression and Parkinson's disease based on bioinformatics methods

作　　者：王杰 陈聪聪 王璐茜 WANG Jie;CHEN Congcong;WANG Luxi(Entitled Group One Ward,The Seventh People's Hospital of Wenzhou City,Wenzhou 325000,China)

机构地区：[1]温州市第七人民医院优抚一病区,浙江温州325000 [2]温州医科大学附属第一医院神经内科

出　　处：《全科医学临床与教育》2025年第2期105-108,137,F0002,F0003,共7页Clinical Education of General Practice

基　　金：浙江省自然科学基金项目(LQ19H090011)。

摘　　要：目的采用生物信息学方法分析重度抑郁症(MDD)和帕金森病(PD)的基因数据,寻找MDD与PD的共同关键基因。方法从GEO数据库获取MDD与PD的基因数据集,使用GEO2R进行分析筛选出共同差异基因。通过基因本体论、京都基因与基因组百科全书数据库进行通路富集分析,并构建蛋白质-蛋白质相互作用网络探索MDD与PD的共同关键基因。通过DGIdb数据库寻找候选药物。建立诊断模型并通过ROC曲线评估共同关键基因的诊断价值。结果本研究发现SNAP25、GABRB1、FSTL5、CADPS、KCNIP1此5个基因可能是MDD与PD的共同关键基因,且在该两种疾病中均具有良好的诊断价值。针对以上基因,本研究筛选出10个可同步治疗MDD与PD的候选药物。结论这些共同关键基因的鉴定、共同通路的发现以及候选药物的筛选,为MDD与PD共病的发病机制、诊断生物标志物和药物治疗提供了新的靶点。Objective To use bioinformatics methods to analyze gene data for major depressive disorder(MDD)and Parkinson's disease(PD)and identify common key genes between MDD and PD.Methods Gene datasets for MDD and PD were obtained from the GEO database.Common differentially expressed genes were identified using GEO2R analysis.Pathway enrichment analyses were conducted using Gene Ontology(GO)and the Kyoto Encyclopedia of Genes and Genomes(KEGG)database.A protein-protein interaction(PPI)network was constructed to explore the common key genes between MDD and PD.Candidate drugs were identified using the DGIdb database.A diagnostic model was established,and the diagnostic value of the common key genes was evaluated using ROC curves.Results We identified 5 common key genes of MDD and PD:SNAP25,GABRB1,FSTL5,CADPS and KCNIP1.These 5 genes have good diagnostic values in the two diseases.Based on these genes,we screened out 10 candidate drugs for simultaneous treatment of MDD and PD.Conclusion The identification of these common key genes,the discovery of possible shared pathways and the screening of drug candidates provide new targets for pathogenesis,diagnostic biomarkers and drug therapy of the comorbidity of MDD and PD.

关 键 词：抑郁症 帕金森病 差异基因 通路富集分析 生物信息学分析 

分 类 号：R749.4[医药卫生—神经病学与精神病学] R742.5[医药卫生—临床医学] Q811.4[生物学—生物工程]