阿尔茨海默病海马区MRI扫描SWI序列影像学特征研究  

Imaging characteristics of MRI SWI sequence of the hippocampus in Alzheimer disease

作　　者：韩倩倩 李昕 徐世达 HAN Qianqian;LI Xin;XU Shida(Department of Radiology,The Second People's Hospital of Lishui,Lishui 323000,China)

机构地区：[1]丽水市第二人民医院放射科,浙江丽水323000 [2]丽水市中医医院放射科

出　　处：《全科医学临床与教育》2025年第2期134-137,共4页Clinical Education of General Practice

基　　金：浙江省中医药科技计划项目(2024ZL1284)。

摘　　要：目的分析阿尔茨海默病(AD)海马区磁共振(MRI)扫描磁敏感加权成像(SWI)序列的影像学特征。方法选择经临床诊断为AD的患者68例、轻度认知功能障碍阶段(aMCI)患者30例及健康体检的认知功能评定简易智能状态检查表(MMSE)评分>25分的30例健康者分别纳入AD组、aMCI组、对照组;比较三组MRI扫描SWI序列影像参数,线性回归分析其与AD的关系。结果与对照组比较,AD组、aMCI组患者左侧海马相位值、右侧海马相位值明显更低,左侧海马相对体积、右侧海马相对体积明显更小(q分别=4.16、3.22、4.36、2.83、65.58、32.70、27.59、18.98,P均<0.05);与aMCI组比较,AD组左侧海马相位值、右侧海马相对体积明显更小(q分别=27.06、5.24,P均<0.05),但相位值比较,差异无统计学意义(q分别=0.45、1.52,P均>0.05)。与对照组比较,AD组左右侧侧脑室下静脉的直径、长度更短,分支数更少(q分别=43.34、30.86、7.56;26.96、20.90、23.08,P均<0.05),与aMCI组比较,AD组左右侧侧脑室下静脉的直径、长度更短,分支数更少(q分别=19.95、38.43、19.09;22.70、20.95、23.08,P均<0.05)。结论AD患者海马区体积以及静脉血管形态均发生不同程度变化,将SWI作为常规MRI序列的重要补充,可精确显示静脉血管形态变化,或有助于AD的早期诊断。Objective To analyze the imaging characteristics of magnetic resonance imaging(MRI)susceptibility weighted imaging(SWI)sequence of the hippocampus in Alzheimer disease(AD).Methods A total of 68 patients with AD,30 patients with mild cognitive impairment(aMCI)and 30 healthy individuals who received health check-ups and mini-mental state examination(MMSE)score higher than 25 were selected as AD group,aMCI group and control group,respectively.Imaging parameters of MRI SWI sequence in the three groups were compared,and their relationship with AD was discussed through linear regression analysis.Results Compared with the control group,phase values and relative volume of left and right hippocampi in AD group and aMCI group were significantly smaller(q=4.16,3.22,4.36,2.83,65.58,32.70,27.59,18.98,P<0.05).Compared with aMCI group,phase value of left hippocampus and relative volume of right hippocampus in AD group were significantly smaller(q=27.06,5.24,P<0.05),but there was no statistically significant difference in phase value of right hippocampus(q=0.45,1.52,P>0.05).Compared with the control group,the diameter,length and number of branches of left and right subventricular veins in AD group were significantly smaller(q=43.34,30.86,7.56,26.96,20.90,23.08,P<0.05).Compared with aMCI group,the diameter,length and number of branches of left and right subventricular veins in AD group were smaller(q=19.95,38.43,19.09,22.70,20.95,23.08,P<0.05).Conclusion There are different degrees of changes in the volume of the hippocampus and the morphology of veins in patients with AD.Using SWI as an important supplement to conventional MRI sequences can accurately display changes in the morphology of veins,which may contribute to the early diagnosis of AD.

关 键 词：阿尔茨海默病 海马区 磁共振 磁敏感加权成像 

分 类 号：R74[医药卫生—神经病学与精神病学]