抑郁症快感缺失的神经影像学机制研究进展  

Research progress on the neuroimaging mechanism of anhedonia in major depressive disorder

作　　者：罗世杰 张一靓 钟舒明[1] 赖顺凯 贾艳滨[1] Luo Shijie;Zhang Yiliang;Zhong Shuming;Lai Shunkai;Jia Yanbin(Department of Psychiatry,the First Affiliated Hospital of Jinan University,Guangzhou 510630,China)

机构地区：[1]暨南大学附属第一医院精神医学科,广州510630

出　　处：《中华精神科杂志》2025年第2期147-151,共5页Chinese Journal of Psychiatry

基　　金：国家重点研发计划(2022YFB4500600);国家自然科学基金(82271564);广州市科技计划重点项目(202206060001);广州市科技计划项目(2023B03J1300,2024A04J4178)。

摘　　要：快感缺失是抑郁症核心症状之一,其发病机制尚不明确。快感缺失可能与前额叶、纹状体、海马、杏仁核和中脑腹侧被盖等脑区奖赏过程中的调控作用有关。本文拟通过总结上述脑区参与奖赏预期、决策和反馈等过程中的关键作用,综述各脑区炎症反应、神经递质代谢、基因表达异常影响抑郁症快感缺失症状的神经影像学机制。Anhedonia is one of the core symptoms of major depressive disorder,and its underlying mechanisms remain unclear.The regulation of the reward process in brain regions,such as the hippocampus,amygdala,striatum,ventral tegmental brain,and prefrontal lobe,may play a role in anhedonia.This study has concluded the changes in relevant brain regions in reward anticipation,decision-making,and feedback processes.The neuroimaging mechanisms of inflammation,neurotransmitter metabolism,and gene expression on depression anhedonia symptoms were reviewed.

关 键 词：抑郁症 快感缺失 奖赏环路 炎症反应 代谢紊乱 

分 类 号：R749.4[医药卫生—神经病学与精神病学]