干眼的炎症反应机制及抗炎治疗研究进展  

Advances in inflammatory response mechanism and anti-inflammatory treatment with dry eye disease

作　　者：王萍萍 蒋凡 李思敏 闫东霞 程娟[2] Wang Pingping;Jiang Fan;Li Simin;Yan Dongxia;Cheng Juan(The First Clinical College of Shanxi University of Traditional Chinese Medicine,Jinzhong 030619,Shanxi Province,China;Shanxi Eye Hospital,Taiyuan 030002,Shanxi Province,China)

机构地区：[1]山西中医药大学第一临床学院,中国山西省晋中市030619 [2]山西省眼科医院,中国山西省太原市030002

出　　处：《国际眼科杂志》2025年第3期440-445,共6页International Eye Science

基　　金：山西省中医药管理局科研课题(No.2023ZYYA027)。

摘　　要：近年来,干眼患病率逐步增加,已成为最常见的眼表疾病之一。炎症反应是干眼发病的病理基础,这一过程中参与的炎症介质和炎症信号通路多种多样,因此抗炎治疗是预防控制干眼的基础治疗。文章总结了干眼发生发展过程中经典炎症因子:白细胞介素、肿瘤坏死因子、基质金属蛋白酶、趋化因子、细胞黏附因子;相关炎症信号转导通路:MAPKs通路、NF-κB通路、Wnt通路、TLR通路;目前一线推荐抗炎治疗药物:糖皮质激素、免疫抑制剂、非甾体类抗炎药和中医抗炎治疗的作用机制及相关指标的水平变化,以期系统地了解干眼的炎症反应机制及治疗前景。In recent years,the incidence of dry eye disease(DED)is increasing,positioning it as one of the most prevalent diseases affecting the ocular surface.Inflammatory response is the pathological basis of DED,involving various inflammatory mediators and inflammatory signaling pathways.Consequently,anti-inflammatory treatment emerges as a fundamental strategy for preventing and managing DED.This review summarizes the classic inflammatory factors involved in the development and progression of DED,including interleukins,tumor necrosis factor,matrix metalloproteinases,chemokines,and cell adhesion molecules.It also discusses the relevant inflammatory signaling pathways:the MAPKs pathway,NF-κB pathway,Wnt pathway and TLR pathway.Additionally,this review addresses the mechanisms of action and alterations in relevant biomarkers associated with current first-line recommended anti-inflammatory therapies,including corticosteroids,immunosuppressants,nonsteroidal anti-inflammatory drugs,and traditional Chinese medicine approaches to inflammation management.This comprehensive overview aims to enhance understanding of the inflammatory mechanisms underlying DED while exploring future therapeutic prospects.

关 键 词：干眼 炎症因子 炎症信号通路 抗炎 

分 类 号：R777.34[医药卫生—眼科]