血清HDAC1和eNOS水平对白内障术后感染性眼内炎的预测价值  

Predictive value of serum histone deacetylase 1 and endothelial nitric oxide synthase levels for infectious endophthalmitis after cataract surgery

作　　者：阎晓庆 庞星宇 郝莉莉 Yan Xiaoqing;Pang Xingyu;Hao Lili(Department of Functional Examination,Zhangjiakou Fourth Hospital,Zhangjiakou 075000,Hebei Province,China;Department of Clinical Laboratory,Zhangjiakou Fourth Hospital,Zhangjiakou 075000,Hebei Province,China;Department of Ocular Trauma,Zhangjiakou Fourth Hospital,Zhangjiakou 075000,Hebei Province,China)

机构地区：[1]中国河北省张家口市第四医院功能科,075000 [2]中国河北省张家口市第四医院检验科,075000 [3]中国河北省张家口市第四医院眼外伤科,075000

出　　处：《国际眼科杂志》2025年第3期490-493,共4页International Eye Science

基　　金：张家口市重点研发计划项目(No.2322170D)。

摘　　要：目的:探究血清组蛋白去乙酰化酶1(HDAC1)和内皮型一氧化氮合酶(eNOS)在白内障术后感染性眼内炎的预测价值。方法:选取2020-01/2023-01在本院收治的362例362眼白内障患者为研究对象,根据术后是否发生感染性眼内炎将362例362眼分为感染组(15例15眼)和未感染组(347例347眼)。采用酶联免疫吸附法(ELISA)对所有受试者血清HDAC1、eNOS水平进行测定,并比较两组患者血清HDAC1、eNOS水平;多因素Logistic回归分析发生感染性眼内炎的影响因素;受试者工作特征曲线(ROC)分析血清HDAC1、eNOS水平对白内障患者术后发生感染性眼内炎的预测价值。结果:术前1 d,感染组患者血清HDAC1、eNOS水平均显著高于未感染组(均P<0.01)。手术时间、玻璃体溢出、HDAC1、eNOS均是发生感染性眼内炎的危险因素(均P<0.05)。ROC结果显示,HDAC1、eNOS单独预测发生感染性眼内炎的AUC分别为0.878、0.877,敏感度分别为88.7%、87.7%,特异度分别为70.4%、7.8%,二者联合预测白内障患者术后发生感染性眼内炎的AUC为0.978,敏感度为86.7%,特异度为85.3%。结论:白内障术后发生感染性眼内炎患者血清HDAC1、eNOS水平显著升高,且血清HDAC1联合eNOS检测有助于提高对白内障患者术后发生感染性眼内炎的预测效能,两者可为临床诊疗提供参考。AIM:To investigate the predictive value of serum histone deacetylase 1(HDAC1)and endothelial nitric oxide synthase(eNOS)for infectious endophthalmitis after cataract surgery.METHODS:A total of 362 cataract patients(362 eyes)admitted to our hospital from January 2020 to January 2023 were selected as the research objects.According to the occurrence of postoperative infectious endophthalmitis,they were divided into infection group(15 cases,15 eyes)and non-infection group(347 cases,347 eyes).Enzyme linked immunosorbent assay(ELISA)was applied to detect the levels of serum HDAC1 and eNOS in all subjects,and the levels of serum HDAC1 and eNOS in both groups were compared;the influencing factors of infectious endophthalmitis were analyzed by multivariate Logistic regression;the receiver operative curve(ROC)was applied to analyze the predictive value of serum HDAC1 and eNOS levels for postoperative infectious endophthalmitis in cataract patients.RESULTS:The levels of serum HDAC1 and eNOS in the infected group were obviously higher than those in the uninfected group(all P<0.01).Surgical time,vitreous overflow,HDAC1,and eNOS were all risk factors for postoperative infectious endophthalmitis(all P<0.05).ROC results showed that the AUC of HDAC1 and eNOS in predicting postoperative infectious endophthalmitis in cataract patients was 0.878 and 0.877,respectively,with sensitivity of 88.7%and 87.7%,specificity of 70.4%and 7.8%,respectively,while the AUC of the two combination in predicting postoperative infectious endophthalmitis in cataract patients was 0.978,with a sensitivity of 86.7%and a specificity of 85.3%.CONCLUSION:The serum levels of HDAC1 and eNOS in patients with infectious endophthalmitis after cataract surgery are obviously increased,and the combined detection of serum HDAC1 and eNOS can improve the predictive efficacy of infectious endophthalmitis in cataract patients after surgery.Both can provide reference for clinical diagnosis and treatment.

关 键 词：组蛋白去乙酰化酶1(HDAC1) 内皮型一氧化氮合酶(eNOS) 白内障 感染性眼内炎 

分 类 号：R779.66[医药卫生—眼科]