旋覆代赭汤合小陷胸汤加减联合PPIs降阶梯撤药对非糜烂性反流病的效果  

The Effect of Xuanfu Daizhe Decoction and Xiaoxianxiong Decoction Modified Combined with PPIs to Step Down and Withdraw Medication on Non Erosive Reflux Disease

作　　者：张安 ZHANG An(Department of Traditional Chinese Medicine,First Affiliated Hospital of Tsinghua University,Beijing 100016,China)

机构地区：[1]清华大学第一附属医院中医科,北京100016

出　　处：《中国医学创新》2025年第5期118-122,共5页Medical Innovation of China

摘　　要：目的:探究旋覆代赭汤合小陷胸汤加减联合质子泵抑制剂(PPIs)降阶梯撤药治疗非糜烂性反流病(NERD)的效果。方法:选择2021年1月-2024年1月在清华大学第一附属医院治疗的NERD患者80例,根据随机数字表法分为两组,均40例,对照组采用PPIs降阶梯撤药治疗,试验组采用旋覆代赭汤合小陷胸汤加减联合PPIs降阶梯撤药治疗,两组在治疗12周后评价治疗效果,对比两组临床疗效、病情状况、胃肠自主神经功能、血清指标、生活质量。结果:试验组总有效率高于对照组(P<0.05)。治疗后,试验组反流性疾病问卷(RDQ)各项评分、胃肠自主神经功能低频功率(LF)值均高于对照组,胃肠自主神经功能高频功率(HF)值、5-羟色胺(5-HT)、血管活性肠肽(VIP)、胃食管反流病问卷(GerdQ)均低于对照组,差异均有统计学意义(P<0.05)。结论:NERD患者接受旋覆代赭汤合小陷胸汤加减联合PPIs降阶梯撤药治疗,效果显著,可改善胃肠自主神经功能及胃肠动力,提高生活质量。Objective:To investigate the effect of Xuanfu Daizhe Decoction and Xiaoxianxiong Decoction modified combined with proton pumb inhibitors(PPIs)step down and withdraw medication in the treatment of non erosive reflux disease(NERD).Method:Eighty NERD patients treated at the First Affiliated Hospital of Tsinghua University from January 2021 to January 2024 were randomly divided into two groups,with 40 patients in each group.The control group was treated with PPIs step down and withdraw medication,while the experimental group was treated with Xuanfu Daizhe Decoction and Xiaoxianchest Decoction modified combined with PPIs step down and withdraw medication.Two groups evaluated the treatment effect after 12 weeks of treatment.The clinical efficacy,disease status,gastrointestinal autonomic nervous function,serum indicators,and quality of life of the two groups were compared.Result:The total effective rate of the experimental group was higher than that of the control group(P<0.05).After treatment,the scores of various items reflux disease questionnaire(RDQ)and low-frequency power(LF)of gastrointestinal autonomic nervous function in the experimental group were higher than those in the control group,the high-frequency power(HF)of gastrointestinal autonomic nervous function,5-hydroxytryptamine(5-HT),vasoactive intestinal peptide(VIP),and gastroesophageal reflux disease questionnaire(GerdQ)were lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion:NERD patients receiving modified combination of Xuanfu Daizhe Decoction and Xiaoxianxiong Decoction combined with PPIs for step down and withdraw medication therapy have significant effects,which can improve gastrointestinal autonomic nervous system function and gastrointestinal motility,and enhance quality of life.

关 键 词：旋覆代赭汤合小陷胸汤加减 质子泵抑制剂 降阶梯撤药 非糜烂性反流病 

分 类 号：R571[医药卫生—消化系统]