Neuroform EZ支架在症状性大脑中动脉M1段狭窄病变介入治疗中的效果及对神经损伤的影响  

Application Effect of Neuroform EZ Stent in Interventional Treatment of Patients with Symptomatic Stenosis of the M1 Segment of the Middle Cerebral Artery and Influence on Neurological Injury

作　　者：吴亮[1] 彭富[1] 周传凯[1] 牙政锋 廖振南 WU Liang;PENG Fu;ZHOU Chuankai;YA Zhengfeng;LIAO Zhennan(Department of Cerebrovascular Disease,Qinzhou Second People's Hospital,Qinzhou 535000,China;不详)

机构地区：[1]钦州市第二人民医院脑血管病科,广西钦州535000

出　　处：《中国医学创新》2025年第6期63-67,共5页Medical Innovation of China

基　　金：广西壮族自治区卫生健康委员会自筹经费科研课题(Z20211407)。

摘　　要：目的:探讨Neuroform EZ支架在症状性大脑中动脉M_(1)段狭窄病变介入治疗中的效果及对神经损伤的影响。方法:将2021年1月—2023年3月在钦州市第二人民医院住院治疗的80例症状性大脑中动脉M_(1)段狭窄患者根据随机数字表法分为对照组40例和观察组40例。对照组进行药物治疗,观察组则在对照组的基础上采用Neuroform EZ支架治疗。治疗6个月和12个月后随访。比较两组的治疗总有效率、不良血管事件发生率、治疗前后的脑血流灌注情况[脑血容量(CBV)及脑血流量(CBF)]、美国国立卫生研究院卒中量表(NIHSS)评分、改良Rankin量表(MRS)评分及神经损伤指标[血清神经元特异性烯醇化酶(NSE)及S100钙结合蛋白B(S100B)]。结果:观察组的治疗总有效率显著高于对照组,不良血管事件发生率显著低于对照组(P<0.05);治疗前两组的血流灌注情况、NIHSS评分、MRS评分及神经损伤指标比较,差异均无统计学意义(P>0.05),治疗6个月及12个月后观察组的CBV及CBF均显著高于对照组,治疗1周及2周后NIHSS评分、MRS评分及神经损伤指标均显著低于对照组(P<0.05)。结论:Neuroform EZ支架在症状性大脑中动脉M_(1)段狭窄病变介入治疗中的效果确切,且可有效控制神经损伤,因此在症状性大脑中动脉M_(1)段狭窄患者中的应用价值较高。Objective:To investigate the application effect of Neuroform EZ stent in interventional treatment of patients with symptomatic M_(1)segment stenosis of middle cerebral artery and influence on neurological injury.Method:A total of 80 patients with symptomatic M_(1)segment stenosis of middle cerebral artery hospitalized in Qinzhou Second People's Hospital from January 2021 to March 2023 were divided into control group 40 cases and observation group 40 cases by the random number table.The control group was treated with medicine treatment,the observation group was treated with Neuroform EZ stent on the treatment of control group.The patients were followed up after 6 and 12 months of treatment.The total effective rates,adverse vascular events rates,cerebral blood flow perfusion situation[cerebral blood volume(CBV)and cerebral blood flow(CBF)],national institute of health stroke scale(NIHSS)score,modified Rankin scale(MRS)score and neurological injury indexes[serum neuron-specific enolase(NSE)and S100 calcium-binding protein B(S100B)]before and after the treatment of two groups were compared.Result:The total postoperative effective rate of observation group was significantly higher than that of control group,the adverse vascular events rate was significantly lower than that of control group(P<0.05),the cerebral blood flow perfusion situation,NIHSS score,MRS score and neurological injury indexes of two groups before the treatment were compared,the differences were not statistically significant(P>0.05),the CBV and CBF of observation group after 6 and 12 months of the treatment were significantly higher than those of control group,the NIHSS scores,MRS scores and neurological injury indexes after 1 and 2 weeks of the treatment were all significantly lower than those of control group(P<0.05).Conclusion:The effect of Neuroform EZ stent in interventional treatment of patients with symptomatic stenosis of the M_(1)segment of the middle cerebral artery is better,and it can effectively control the neurological injury of patients

关 键 词：Neuroform EZ支架 症状性大脑中动脉M_(1)段狭窄 神经损伤 

分 类 号：R743.3[医药卫生—神经病学与精神病学]