结直肠息肉患者高同型半胱氨酸血症与肾功能的相关性分析  

Correlation Analysis between Hyperhomocysteinemia and Renal Function in Patients with Colorectal Polyps

作　　者：罗艺珍[1] 仇继峰 黄林妮 LUO Yizhen;QIU Jifeng;HUANG Linni(Department of Gastroenterology,Lingshan County People's Hospital,Lingshan 535400,China;不详)

机构地区：[1]灵山县人民医院消化内科,广西灵山535400

出　　处：《中国医学创新》2025年第6期108-111,共4页Medical Innovation of China

基　　金：钦州市科学研究与技术开发计划项目(20213722)。

摘　　要：目的:探索结直肠息肉患者同型半胱氨酸(homocysteine,Hcy)水平与肾功能的相关性。方法:选取2021年7月—2023年7月于灵山县人民医院进行结肠镜检查的结直肠息肉患者121例为研究对象,按血清Hcy水平将患者分为对照组(血清Hcy水平<15μmol/L)77例和高同型半胱氨酸血症(hyperhomocysteinemia,HHcy)组(血清Hcy水平≥15μmol/L)44例,比较两组患者的临床特征和肾功能差异,分析结直肠息肉患者血清Hcy水平与肾功能的相关性。结果:与对照组比较,HHcy组患者的血清肌酐、尿素氮、尿酸水平均显著高,差异均有统计学意义(P<0.05);经Pearson相关系数分析,两组患者血清肌酐、尿酸水平与Hcy水平均呈正相关(r=0.407、0.315,P<0.05)。结论:血清肌酐、尿酸水平与血清Hcy水平有相关性,对于HHcy水平结直肠息肉患者,需要监测肾功能。Objective:To explore the correlation between homocysteine(Hcy)level and renal function in patients with colorectal polyps.Method:A total of 121 cases with colorectal polyps who underwent colonoscopy in Lingshan County People's Hospital from July 2021 to July 2023 were selected as the study objects.According to serum Hcy level,the patients were divided into control group(Hcy<15μmol/L)with 77 cases,and hyperhomocysteinemia(HHcy)group(Hcy≥15μmol/L)with 44 cases.The clinical features and renal function of the two groups were compared,and the correlation between serum Hcy level and renal function in patients with colorectal polyps was analyzed.Result:Compared with control group,serum creatinine,urea and uric acid levels in HHcy group were significantly higher,with statistical significance(P<0.05).According to Pearson correlation coefficient analysis,serum creatinine and uric acid levels were positively correlated with Hcy levels in two groups(r=0.407,0.315,P<0.05).Conclusion:Serum creatinine and uric acid levels are associated with serum Hcy levels,and for patients with HHcy levels of colorectal polyps,it is necessary to monitor renal function.

关 键 词：结直肠息肉 高同型半胱氨酸血症 肾功能 相关性分析 

分 类 号：R574[医药卫生—消化系统]