胸腔镜下亚叶切除术对肺癌患者肺功能及肿瘤标志物水平的影响  

Effect of thoracoscopic sublobectomy on lung function and tumor marker levels in patients with lung cancer

作　　者：李倩 任玉雪 曹艳 LI Qian;REN Yuxue;CAO Yan(Fifth Ward,Department of Thoracic Surgery,He’nan Provincal Chest Hospital(Chest Hospital Affiliated to Zhengzhou University),Zhengzhou 450000,He’nan,China)

机构地区：[1]河南省胸科医院(郑州大学附属胸科医院)胸外五病区,郑州450000

出　　处：《癌症进展》2025年第1期51-54,共4页Oncology Progress

摘　　要：目的探讨胸腔镜下亚叶切除术对肺癌患者肺功能及肿瘤标志物水平的影响。方法根据手术方法的不同将100例肺癌患者分为对照组(n=47,胸腔镜下肺叶切除术)和观察组(n=53,胸腔镜下亚叶切除术)。比较两组患者的围手术期指标、肺通气功能指标[呼气流量峰值(PEF)、最大自主通气量(MVV)、用力肺活量(FVC)、第1秒用力呼气容积(FEV_(1))]及肿瘤标志物[癌胚抗原(CEA)、鳞状细胞癌抗原(SCC-Ag)、细胞角质蛋白19片段抗原21-1(CYFRA21-1)]水平。结果观察组患者手术时间和住院时间均短于对照组,术中出血量少于对照组,术后并发症发生率低于对照组,差异均有统计学意义(P﹤0.05)。术后3个月,两组患者PEF、MVV、FVC、FEV_(1)均低于本组术前,观察组患者PEF、MVV、FVC、FEV_(1)均高于对照组,差异均有统计学意义(P﹤0.05);术后1年,两组患者PEF、MVV、FVC、FEV_(1)均高于本组术前及术后3个月,观察组患者PEF、MVV、FVC、FEV_(1)均高于对照组,差异均有统计学意义(P﹤0.05)。术后3个月及术后1年,两组患者CEA、SCC-Ag、CYFRA21-1水平均低于本组术前,观察组患者CEA、SCC-Ag、CYFRA21-1水平均低于对照组,差异均有统计学意义(P﹤0.05)。结论与胸腔镜下肺叶切除术相比,胸腔镜下亚叶切除术对肺癌患者肺功能的影响更小,更有利于患者术后恢复,且能够降低术后并发症发生率和肿瘤标志物水平。Objective To explore the effect of thoracoscopic sublobectomy on lung function and tumor marker levels in patients with lung cancer.Method According to different surgical methods,100 patients with lung cancer were divided into control group(n=47,thoracoscopic lobectomy)and observation group(n=53,thoracoscopic sublobectomy).The perioperative indexes,pulmonary ventilation function indexes[peak expiratory flow(PEF),maximal voluntary ventilation(MVV),forced vital capacity(FVC),forced expiratory volume in one second(FEV_(1))]and tumor markers[carcinoembryonic antigen(CEA),squamous cell carcinoma antigen(SCC-Ag)and cyto-keratin 19 fragment antigen 21-1(CYFRA21-1)]levels were compared between the two groups.Result The operation time and hospital stay in observation group were shorter than those in control group,the amount of intraoperative blood loss was less than that in control group,and the incidence of postoperative complications was lower than that in control group,the differences were statistically significant(P<0.05).Three months after surgery,the PEF,MVV,FVC and FEV_(1) in both groups were lower than those before surgery,and the PEF,MVV,FVC and FEV_(1) in observation group were higher than those in control group,the differences were statistically significant(P<0.05).One year after surgery,the PEF,MVV,FVC and FEV_(1) in both groups were higher than those before surgery and 3 months after surgery,and the PEF,MVV,FVC and FEV_(1) in observation group were higher than those in control group,the differences were statistically significant(P<0.05).Three months and one year after surgery,the CEA,SCC-Ag and CYFRA21-1 levels in both groups were lower than those before surgery,and the CEA,SCC-Ag and CYFRA21-1 levels in observation group were lower than those in control group,and the differences were statistically significant(P<0.05).Conclusion Compared with thoracoscopic lobectomy,thoracoscopic sublobectomy has less impact on lung function in patients with lung cancer,which is more conducive to postoperative recovery of pat

关 键 词：胸腔镜下亚叶切除术 胸腔镜下肺叶切除术 肺通气功能指标 肿瘤标志物 

分 类 号：R734.2[医药卫生—肿瘤]