夹心式序贯放化疗治疗子宫内膜癌的疗效及预后影响因素分析  

Effect of sandwich sequential chemoradiotherapy on the treatment of endometrial carcinoma and the influencing factor of prognosis

作　　者：张丽 姜敏[1] 刘弘扬[1] ZHANG Li;JIANG Min;LIU Hongyang(Department of Obstetrics and Gynecology,the Third Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,He’nan,China)

机构地区：[1]郑州大学第三附属医院妇产科,郑州450000

出　　处：《癌症进展》2025年第1期55-58,共4页Oncology Progress

摘　　要：目的探讨夹心式序贯放化疗治疗子宫内膜癌(EC)的疗效及预后影响因素。方法选取110例EC患者,均完成夹心式序贯放化疗,记录患者治疗效果和预后情况,比较预后良好组和预后不良组患者的临床特征,分析EC患者预后的影响因素。结果110例EC患者治疗后完全缓解32例,部分缓解42例,稳定28例,进展8例,客观缓解率为67.27%,疾病控制率为92.73%。经随访,预后不良34例,预后良好76例。预后不良组患者中临床分期为Ⅲ~Ⅳ期、有淋巴脉管间隙浸润(LVSI)、子宫下段受累比例及血清糖类抗原125(CA125)、人附睾蛋白4(HE4)水平均高于预后良好组,差异均有统计学意义(P﹤0.05)。Logistic回归分析结果显示,临床分期为Ⅲ~Ⅳ期、LVSI、子宫下段受累及血清CA125、HE4水平升高均为EC患者预后不良的危险因素(P﹤0.05)。结论夹心式序贯放化疗治疗EC可提高临床疗效,临床分期高、LVSI、子宫下段受累及血清CA125、HE4水平升高均是导致预后不良的相关因素。Objective To investigate the effect of sandwich sequential chemoradiotherapy on the treatment of endometrial carcinoma(EC)and the influencing factor of prognosis.Method A total of 110 patients with EC were selected and treated with sandwich sequential chemoradiotherapy.The therapeutic effect and prognosis were recorded.The clinical characteristics of patients with good prognosis and poor prognosis were compared,and the influencing factors of the prognosis of EC patients were analyzed.Result Among 110 EC patients,32 cases were complete response,42 cases were partial response,28 cases were stable,8 cases were progressive,the objective response rate was 67.27%,the disease control rate was 92.73%.After follow-up,34 cases had poor prognosis and 76 cases had good prognosis.Proportion of clinical stage Ⅲ-Ⅳ,lymphovascular space infiltration(LVSI),lower uterine involvement and levels of serum carbohydrate antigen 125(CA125)and human epididymal protein 4(HE4)in the poor prognosis group were higher than those in the good prognosis group,the differences were statistically significant(P<0.05).Logistic regression analysis showed that clinical stage Ⅲ~Ⅳ,LVSI,lower uterine involvement and elevated serum CA125 and HE4 levels were risk factors for poor prognosis in EC patients(P<0.05).Conclusion Sandwich sequential chemoradiotherapy can improve the clinical efficacy of EC.High clinical stage,LVSI,lower uterine involvement and elevated serum CA125 and HE4 levels are related factors leading to poor prognosis.

关 键 词：子宫内膜癌 序贯放化疗 预后 临床分期 糖类抗原125 

分 类 号：R737.33[医药卫生—肿瘤]