胼胝体病变临床疾病谱及影像学特征分析  

Analysis of the clinical disease spectrum and imaging features of corpus callosum lesions

作　　者：唐海 尚晓娜 桑苗苗 王雅楠 高修明 TANG Hai;SHANG Xiaona;SANG Miaomiao;WANG Ya’nan;GAO Xiuming(The Affiliated Hospital of Xuzhou Medical University,Xuzhou 221002,China;The First College of Clinical Medicine,Xuzhou Medical University,Xuzhou 221004,China)

机构地区：[1]徐州医科大学附属医院,江苏徐州221002 [2]徐州医科大学第一临床医学院,江苏徐州221004

出　　处：《中国实用神经疾病杂志》2025年第2期152-156,共5页Chinese Journal of Practical Nervous Diseases

基　　金：徐州市科技局重点研发计划(社会发展)项目(编号:KC22131);徐州市卫生健康委青年科技创新重点项目(编号:XWKYSL20210164);徐州市卫生健康委科技项目面上项目(编号:XWKYT20210583);徐州医科大学附属医院课题(编号:2020KB003)。

摘　　要：目的探讨胼胝体病变临床疾病谱及影像学特征,提高其临床诊疗水平。方法收集2020-01-2023-01徐州医科大学附属医院收治的81例胼胝体病变患者的临床资料,所有患者均行MRI检查,分析临床及影像学资料。结果81例患者发病年龄(50.75±19.34)岁,其中脑血管性疾病48例,肿瘤性疾病14例,先天性畸形8例,脱髓鞘性疾病4例,可逆性胼胝体压部综合征4例,代谢变性中毒性疾病3例,病因复杂。临床表现肢体无力35例,认知障碍20例,共济运动失调21例,言语障碍16例,异己手综合征15例,感觉障碍14例,视觉障碍12例,癫痫10例,部分病例表现不典型。MRI提示累及胼胝体膝部24例,体部42例,压部56例,额叶、顶叶、枕叶亦可见受累,部分病例影像学特征明显。结论胼胝体病变疾病谱复杂,临床表现多样,部分病例影像学表现具有一定特征性。Objective To investigate the clinical manifestations and imaging characteristics of the disease spectrum associated with corpus callosum lesions,with the ultimate goal of enhancing the current diagnostic and therapeutic approaches.Methods From January 2020 to January 2023,81 patients with corpus callosum lesions were admitted to the Affiliated Hospital of Xuzhou Medical University.All patients underwent an MRI examination,and a retrospective analysis of clinical and imaging data was conducted.Results The analysis encompassed 81 patients with an age of onset(50.75±19.34)years.The cohort consisted of 48 cases of cerebrovascular diseases,14 cases of neoplastic diseases,8 cases of congenital anomalies,4 cases of demyelinating diseases,4 cases of reversible corpus callosum compression syndrome,3 cases of metabolic degeneration of toxicity,and a complex etiology.Clinical manifestations included limb weakness in 35 cases,cognitive impairment in 20 cases,ataxia in 21 cases,speech disorders in 16 cases,alien hand syndrome in 15 cases,sensory disorders in 14 cases,visual impairment in 12 cases,epilepsy in 10 cases,and atypical presentations in some cases.MRI revealed involvement of the corpus callosum knee in 24 cases,42 cases of corpus callosum involvement,56 cases of corpus callosum pressure,and involvement of the frontal,parietal,and occipital lobes in some cases.The imaging features were distinct,showcasing the complexity of the disease.Conclusion The complex disease spectrum of corpus callosum lesions presents a diverse range of clinical manifestations,and some cases have certain imaging characteristics.

关 键 词：胼胝体 MARCHIAFAVA-BIGNAMI病 临床表现 磁共振成像 影像学特征 疾病谱 

分 类 号：R743.32[医药卫生—神经病学与精神病学]