高频重复经颅磁刺激联合多巴丝肼治疗帕金森病合并焦虑抑郁患者的疗效观察  

Efficacy of high frequency repetitive transcranial magnetic stimulation combined with dopazide in patients with Parkinson’s disease complicated with anxiety and depression

作　　者：赵启媛 丛光燕 吕鸿燕 张勇 李苇 胡盼盼[2] 汪凯[2] ZHAO Qiyuan;CONG Guangyan;LYU Hongyan;ZHANG Yong;LI Wei;HU Panpan;WANG Kai(Lu’an Hospital of Anhui Medical University,Lu’an 237000,China;The First Affiliated Hospital of Anhui Medical University,Hefei 230032,China)

机构地区：[1]安徽医科大学附属六安医院,安徽六安237000 [2]安徽医科大学第一附属医院,安徽合肥230032

出　　处：《中国实用神经疾病杂志》2025年第2期177-180,共4页Chinese Journal of Practical Nervous Diseases

基　　金：国家自然科学基金项目(编号:82171917);安徽省临床医学研究转化专项立项项目(编号:202204295107020006)。

摘　　要：目的探讨高频重复经颅磁刺激(rTMS)与多巴丝肼联用在帕金森病(PD)伴焦虑和抑郁症状患者中的应用价值。方法选取2021-01—2022-12于安徽医科大学附属六安医院接受治疗的76例PD合并焦虑抑郁症患者为研究对象,分为单药物治疗组及高频rTMS联用药物治疗组,对比分析2组患者治疗前和治疗4周后日常生活能力量表(ADL)、汉密尔顿焦虑测评量表(HAMA)及汉密尔顿抑郁测评量表(HAMD)评分。结果单药物治疗组患者与高频rTMS联用药物治疗组患者治疗前的ADL、HAMA、HAMD评分比较均无统计学差异(P>0.05),治疗后的ADL评分[(62.37±10.57)分比(75.16±9.90)分]、HAMA评分[(17.76±3.67)分比(11.87±2.71)分]、HAMD评分[(20.16±2.52)分比(14.82±2.58)分]比较有统计学差异(P<0.01),单药物治疗组治疗后ADL评分较治疗前显著提高(P<0.01),HAMA评分和HAMD评分治疗前后比较差异无统计学意义(P>0.05),高频rTMS联合药物组患者ADL评分、HAMA评分和HAMD评分均较治疗前显著改善,差异有统计学意义(P<0.01)。结论PD合并焦虑抑郁患者应用高频rTMS联合药物治疗,能显著改善其日常生活能力及焦虑抑郁情绪,为临床治疗PD合并焦虑抑郁患者提供了新的治疗思路。Objective To investigate the application value of high-frequency rTMS combined with dopazide in patients with anxiety and depression in PD.Methods Seventy-six patients with PD complicated with anxiety and depression in Lu’an Hospital of Anhui Medical University from January 2021 to December 2022 were selected as the study objects,and were divided into single drug treatment group and high-frequency rTMS combined drug treatment group.ADL,HAMA and HAMD scores between the two groups were compared and evaluated before and after 4 weeks of treatment.Results There were no significant differences in ADL,HAMA and HAMD scores between the single drug treatment group and the high-frequency rTMS combined drug treatment group before treatment(P>0.05).There were significant differences on ADL score(62.37±10.57 vs 75.16±9.90),HAMA score(17.76±3.67 vs 11.87±2.71)and HAMD score(20.16±2.52 vs 14.82±2.58)after treatment(P<0.01).The ADL score of the single drug treatment group after treatment was significantly higher than that before treatment(P<0.01).There were no significant differences on HAMA and HAMD scores before and after treatment in the single drug treatment group(P>0.05).ADL,HAMA and HAMD scores of high-frequency rTMS combined with drug treatment group were significantly improved,and the differences were statistically significant(P<0.01).Conclusion High frequency rTMS combined with drug therapy in PD patients with anxiety and depression can significantly improve daily living ability and anxiety and depression mood,providing a new therapeutic idea for clinical treatment of PD patients with anxiety and depression.

关 键 词：帕金森病 焦虑 抑郁 重复经颅磁刺激 多巴丝肼 日常生活能力 

分 类 号：R742.5[医药卫生—神经病学与精神病学]