颅内动脉瘤术后抗血小板干预临床分析  

Clinical analysis of antiplatelet intervention after intracranial aneurysm surgery

作　　者：肖铮铮[1] 张峰[1] 宋朝军 XIAO Zhengzheng;ZHANG Feng;SONG Chaojun(The First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000,China)

机构地区：[1]河南科技大学第一附属医院,河南洛阳471000

出　　处：《中国实用神经疾病杂志》2025年第2期181-185,共5页Chinese Journal of Practical Nervous Diseases

基　　金：国家自然科学基金资助项目(编号:u1404822)。

摘　　要：目的探讨颅内动脉瘤患者介入手术后采用抗血小板干预对神经功能、炎症因子的影响。方法选取2020-03—2023-03河南科技大学第一附属医院诊治的92例颅内动脉瘤患者为研究对象,分为对照组(予以介入手术治疗)与观察组(介入手术后予抗血小板治疗),各46例。对比2组患者肿瘤坏死因子-α(TNF-α)、白细胞介素-1(IL-1)、白细胞介素-6(IL-6)、NIHSS评分、Barthel指数(BI)、术后血栓和出血发生率、格拉斯哥昏迷量表(GOS)评分。结果术后1周,观察组TNF-α(264.34±28.47比308.25±41.65)、IL-1(113.47±12.69比169.52±28.74)、IL-6(162.57±18.47比204.62±28.96)均低于对照组(t=5.903、12.102、8.302,P<0.05)。术后2周,观察组的NIHSS评分低于对照组(5.20±1.09比9.04±1.67,t=13.079,P<0.05),BI评分高于对照组(77.85±9.40比65.43±7.04,t=7.171,P<0.05)。观察组血栓率低于对照组(P<0.05),2组患者出血率比较,差异无统计学意义(P>0.05),观察组的预后良好率高于对照组(91.30%比69.57%,P<0.05)。结论介入手术后联合抗血小板药物治疗颅内动脉瘤具有较为理想的效果,有利于改善神经功能和降低血清炎性因子。Objective To investigate the effect of antiplatelet intervention on neurological function and inflammatory factors in patients with intracranial aneurysms after interventional surgery.Methods Ninety-two patients with intracranial aneurysm diagnosed and treated in the First Affiliated Hospital of Henan University of Science and Technology from March 2020 to March 2023 were selected,and were divided into control group(receiving interventional surgery)and observation group(receiving antiplatelet therapy after interventional surgery),46 cases in each group.Tumor necrosis factor-α(TNF-α),interleukin-1(IL-1),interleukin-6(IL-6),NIHSS score,Barthel index(BI)score,incidence of postoperative thrombosis and hemorrhage,and Glasgow coma scale(GOS)score were compared between the two groups.Results One week after surgery,TNF-α(264.34±28.47 vs 308.25±41.65),IL-1(113.47±12.69 vs 169.52±28.74),IL-6(162.57±18.47 vs 204.62±28.96)in observation group was lower than that of control group(t=5.903,12.102,8.302,P<0.05).At two weeks after surgery,NIHSS score of the observation group was lower than that of the control group(5.20±1.09 vs 9.04±1.67,t=13.079,P<0.05),and the BI score was higher than that of the control group(77.85±9.40 vs 65.43±7.04,t=7.171,P<0.05).The thrombus rate in the observation group was lower than that in the control group(P<0.05),there was no significant difference in the bleeding rate between the two groups(P>0.05),and the good prognosis rate in the observation group was higher than that in the control group(91.30%vs 69.57%,P<0.05).Conclusion Combined with antiplatelet drugs after interventional surgery for intracranial aneurysm has better effect,which is conducive to improving nerve function and reducing serum inflammatory factors.

关 键 词：颅内动脉瘤 介入手术 抗血小板药物 神经功能 炎性因子 

分 类 号：R739.41[医药卫生—肿瘤]