Correlation of inflammatory markers with depression and sleep disorders accompanying the prodromal stage of Parkinson’s disease  

作　　者：Cheng-Guang Zhang Yu Zhang Ke Xu Shun Wang Yan Bai 

机构地区：[1]Heilongjiang University of Chinese Medicine,Harbin 150040,Heilongjiang Province,China [2]Department of Acupuncture and Moxibustion,Heilongjiang Academy of Traditional Chinese Medicine,Harbin 150001,Heilongjiang Province,China

出　　处：《World Journal of Psychiatry》2025年第3期49-57,共9页世界精神病学杂志(英文)

摘　　要：Parkinson’s disease(PD)is a common neurodegenerative disorder with increasing incidence and disability rates globally,placing a heavy burden on patients and their families.In the prodromal phase of PD,nonmotor symptoms,particularly depression and sleep disorders,are frequent,with profound effects on disease progression and patient quality of life.Emerging research highlights the critical role of inflammatory markers-including interleukins and tumor necrosis factor-in the pathogenesis of prodromal PD.These inflammatory mediators participate in neurodegenerative processes and may induce or exacerbate depressive symptoms and sleep disorders by disrupting the function of the hypothala-micpituitary-adrenal axis and affecting neurotransmitter,including serotonin,metabolism.Understanding their correlations with nonmotor symptoms in prodromal PD remains incomplete,limiting our ability to develop targeted interventions.This comprehensive review aims to investigate the specific correlations between inflammatory markers and nonmotor symptoms-particularly depression and sleep disorders-in prodromal PD.The findings could have important practical applications,potentially leading to the development of new diagnostic tools and therapeutic strategies for managing PD.By identifying and understanding these correlations,healthcare providers may better predict disease progression and implement more effective treatments for nonmotor symptoms in PD.

关 键 词：Parkinson's disease Prodromal Parkinson's disease Inflammatory markers DEPRESSION Sleep disorders 

分 类 号：R749.4[医药卫生—神经病学与精神病学]